| 内部人士股份 | 7,464,864 shares |
内部人士情绪分数
“内部人士情绪分数”用于查找被公司内部人士购入的公司。
它是一个复杂的多因素量化模型的结果，该模型能够辨识具有最高内部人士累积持有水平的公司。该评分模型结合了内部人士在过去90天内买入的净数量、总买入股份占流通股比例，以及内部人士拥有的总股份的指标。该分数的范围从0到100，数值越高表示相对于同行业而言具有更高程度的内部人士持股水平，50为平均值。
更新频率：每日
高管情绪分数
“高管情绪分数”用于查找被公司管理层购入的公司。
根据定义，公司高管是公司内部人士，但与其他内部人士（10%的股东和董事会成员）不同，公司高管每天在公司工作，而且他们使用自己的资金进行交易。（10%的股东和董事会成员通常是基金经理，管理着其他人的资金。）因此，公司高管进行的内幕交易更为重要，应该被适当地重视和关注。
如同“内部人士情绪分数”，“高管情绪分数”也是一个复杂的多因素量化模型的计算结果，该模型能够辨识具有最高高管累积持有水平的公司。
更新频率：每日
关键内部人士指标
此表格显示了公司在各种内部人士指标上的排名。百分位数排名显示了这家公司在美国市场与其他公司相比的表现。排名越高表明公司所处状况越好。
举例来说，一般认为内部人士的买入是一个积极的指标，因此具有更多内部人士买入的公司将排名高于那些内部人士买入较少（甚至有内部人士卖出）的公司。
内部人士买入净数（排名）
N/A
内部人士买入净数是过去90天内买入的内部人士总数减去卖出的内部人士总数。以百分位排名显示（范围从0到100%）。
内部人士买入占流通股比例（排名）
N/A
内部人士买入占流通股比例是内部人士在过去90天内买入的股份总数减去卖出的股份总数，除以总流通股数并乘以100。
内幕交易图表
以下图表显示了Sierra Oncology Inc内部人士交易。内部人士包括公司的高管、董事或重要投资者。一般而言，基于内幕、非公开信息进行交易是非法的。这并不意味着他们在自己的公司进行任何交易都是非法的。但是，他们必须通过Form 4向美国证券交易委员会（SEC）报告所有交易。
内部人员名单及盈利指标
这张表格显示已知的内部人士名单，从向美国证券交易委员会（SEC）披露的申报文件中自动生成。除了姓名、当前职位和董事、高管或10%所有人的任命外，我们还提供了最新披露的持股信息。此外，我们尽可能提供内部人士的历史交易表现。历史交易表现是内部人士实际进行的公开市场买入交易表现的加权平均值。有关此计算方式的更多信息，请查看YouTube网络研讨会。
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| 内部人士 | 平均收益（%） | 持股 数量 |
分拆 调整 |
|---|
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跟踪内部人士买入记录 - 短期收益分析
在这一部分，我们分析了在 SRRA / Sierra Oncology Inc 中进行的每笔非计划的公开市场内部人士买入的盈利情况。这种分析有助于了解内部人士是否持续产生异常的回报，以及是否值得跟踪。该分析基于每笔交易后一年的情况， 结果仅为理论值。 .
以下表格显示了最近的自动交易计划之外的公开市场买入。
经调整价格 已按拆股调整。 经调整股数 已按拆股调整。
追踪内部人士卖出记录 - 短期亏损分析
在这一部分，我们分析了在 SRRA / Sierra Oncology Inc 中进行的每笔非计划的公开市场内部人士卖出所达成的短期亏损规避。如果存在持续的亏损规避模式，可能表明未来的内部人士卖出交易预示着价格的下跌。该分析基于每笔交易后一年的情况， 结果仅为理论值。 .
以下表格显示了最近的自动交易计划之外的公开市场买入。
| 交易日期 | 内部人士 | 报告 股数 |
报告 价格 |
经调整 股数 |
经调整 价格 |
成本基础 | 达到最低利润的 天数 |
达到最低利润时的 价格 |
避免的 最高损失金额($) |
避免的 最高损失率($) |
|---|---|---|---|---|---|---|---|
| 当前未知该内部人士进行过任何未预先计划的公开市场交易。 |
经调整价格 已按拆股调整。 经调整股数 已按拆股调整。
交易历史记录
点击链接图标即可查看完整的交易历史记录。作为 10b5-1 自动交易计划的一部分进行报告的交易，将在标记为 10b-5 的列中显示 X。
| 备案 日期 |
交易 日期 |
表格 | 内部人士 | 股票代码 | 证券种类 | 代码 | 直接 | 执行 价格 |
单位 价格 |
股数 变化 |
价值 变化 (1K) |
剩余 期权 |
剩余 股份 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2022-07-01 | 2022-07-01 | 4 | Vivo Opportunity, LLC By: Vivo Capital Fund IX, L.P. | SRRA | Common Stock | I | 55.0000 | -431,947 | -23,757 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Vivo Opportunity, LLC By: Vivo Opportunity Fund Holdings, L.P. | SRRA | Common Stock | I | 55.0000 | -2,735,853 | -150,472 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Vivo Opportunity, LLC By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 55.0000 | -161,712 | -8,894 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | ORBIMED ADVISORS LLC See footnotes | SRRA | Common Stock | I | 55.0000 | -226,704 | -12,469 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | ORBIMED ADVISORS LLC See footnotes | SRRA | Common Stock | I | 55.0000 | -226,704 | -12,469 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | ORBIMED ADVISORS LLC See footnotes | SRRA | Common Stock | I | 55.0000 | -1,511,362 | -83,125 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Ashiya Mona See footnotes | SRRA | Common Stock | I | 55.0000 | -226,704 | -12,469 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Ashiya Mona See footnotes | SRRA | Common Stock | I | 55.0000 | -226,704 | -12,469 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Ashiya Mona See footnotes | SRRA | Common Stock | I | 55.0000 | -1,511,362 | -83,125 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Aggarwal Gaurav By: Vivo Opportunity Fund Holdings, L.P. | SRRA | Common Stock | I | 55.0000 | -2,735,853 | -150,472 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Klencke Barbara By spouse | SRRA | Common Stock | I | 55.0000 | -5,000 | -275 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Klencke Barbara | SRRA | Common Stock | D | 55.0000 | -10,000 | -550 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Sinclair Andrew See footnotes | SRRA | Common Stock, $0.001 par value | I | 55.0000 | -1,314,127 | -72,277 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Allen Andrew R | SRRA | Common Stock | D | 55.0000 | -1,650 | -91 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | Collard Craig A | SRRA | Common Stock | D | 55.0000 | -13,500 | -742 | 0 | ||||
| 2022-07-01 | 2022-07-01 | 4 | DILLY STEPHEN GEORGE | SRRA | Common Stock | D | 55.0000 | -5,000 | -275 | 0 | ||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 840 | 8,015 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 252 | 2,404 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 588 | 5,611 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 7,175 | 7,175 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 2,152 | 2,152 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 5,023 | 5,023 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | -1,964,771 | 0 | ||||||
| 2022-04-29 | 2022-04-27 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | -175,000 | 0 | ||||||
| 2022-04-07 | 2022-04-06 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.05 | 6,347 | 0 | |||||
| 2022-04-07 | 2022-04-06 | 4 | Turner William D. | SRRA | Common Stock | D | 37.2474 | -6,347 | -236 | 0 | ||||
| 2022-04-07 | 2022-04-06 | 4 | Turner William D. | SRRA | Common Stock | D | 12.0500 | 6,347 | 76 | 6,347 | ||||
| 2022-04-07 | 2022-04-05 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.05 | 100 | 0 | |||||
| 2022-04-07 | 2022-04-05 | 4 | Turner William D. | SRRA | Common Stock | D | 37.0900 | -100 | -4 | 0 | ||||
| 2022-04-07 | 2022-04-05 | 4 | Turner William D. | SRRA | Common Stock | D | 12.0500 | 100 | 1 | 100 | ||||
| 2022-04-04 | 2022-04-04 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 13.04 | 2,000 | 0 | |||||
| 2022-04-04 | 2022-04-04 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 35.1384 | -2,000 | -70 | 0 | ||||
| 2022-04-04 | 2022-04-04 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 13.0400 | 2,000 | 26 | 2,000 | ||||
| 2022-03-22 | 2022-03-18 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.05 | 100 | 0 | |||||
| 2022-03-22 | 2022-03-18 | 4 | Turner William D. | SRRA | Common Stock | D | 37.0500 | -100 | -4 | 0 | ||||
| 2022-03-22 | 2022-03-18 | 4 | Turner William D. | SRRA | Common Stock | D | 12.0500 | 100 | 1 | 100 | ||||
| 2022-03-17 | 2022-03-17 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.05 | 3,453 | 0 | |||||
| 2022-03-17 | 2022-03-17 | 4 | Turner William D. | SRRA | Common Stock | D | 37.0558 | -3,453 | -128 | 0 | ||||
| 2022-03-17 | 2022-03-17 | 4 | Turner William D. | SRRA | Common Stock | D | 12.0500 | 3,453 | 42 | 3,453 | ||||
| 2022-03-14 | 2022-03-14 | 4 | DILLY STEPHEN GEORGE | SRRA | Stock Option (Right to Buy) | D | 31.54 | 165,000 | 165,000 | |||||
| 2022-03-14 | 2022-03-14 | 4 | Jagpal Sukhi | SRRA | Stock Option (Right to Buy) | D | 31.54 | 50,000 | 50,000 | |||||
| 2022-03-14 | 2022-03-14 | 4 | Klencke Barbara | SRRA | Stock Option (Right to Buy) | D | 31.54 | 50,000 | 50,000 | |||||
| 2022-03-14 | 2022-03-14 | 4 | Norrett Kevin | SRRA | Stock Option (Right to Buy) | D | 31.54 | 35,000 | 35,000 | |||||
| 2022-03-14 | 2022-03-14 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 31.54 | 35,000 | 35,000 | |||||
| 2022-03-14 | 2022-03-14 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 31.54 | 35,000 | 35,000 | |||||
| 2022-03-04 | 2022-03-04 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 13.04 | 2,000 | 0 | |||||
| 2022-03-04 | 2022-03-04 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 30.5981 | -2,000 | -61 | 0 | ||||
| 2022-03-04 | 2022-03-04 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 13.0400 | 2,000 | 26 | 2,000 | ||||
| 2022-02-08 | 2022-02-07 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.05 | 10,000 | 0 | |||||
| 2022-02-08 | 2022-02-07 | 4 | Turner William D. | SRRA | Common Stock | D | 32.3225 | -10,000 | -323 | 0 | ||||
| 2022-02-08 | 2022-02-07 | 4 | Turner William D. | SRRA | Common Stock | D | 12.0500 | 10,000 | 120 | 10,000 | ||||
| 2022-02-04 | 2022-02-04 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 13.04 | 2,000 | 0 | |||||
| 2022-02-04 | 2022-02-04 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 29.7800 | -2,000 | -60 | 0 | ||||
| 2022-02-04 | 2022-02-04 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 13.0400 | 2,000 | 26 | 2,000 | ||||
| 2022-02-02 | 2022-02-02 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 27.0000 | 175,000 | 4,725 | 175,000 | ||||
| 2022-02-02 | 2022-02-02 | 4 | Richardson Joshua | SRRA | Common Stock | I | 27.0000 | 175,000 | 4,725 | 175,000 | ||||
| 2022-02-02 | 3 | Longitude Prime Fund, L.P. | SRRA | Common Stock | I | 175,000 | ||||||||
| 2022-02-01 | 2022-01-31 | 4 | Sinclair Andrew See footnotes | SRRA | Common Stock, $0.001 par value | I | 27.0000 | 150,000 | 4,050 | 1,314,127 | ||||
| 2022-02-01 | 2022-01-28 | 4 | Sinclair Andrew See footnotes | SRRA | Series B Warrants (right to buy) | I | 13.20 | -287,471 | 0 | |||||
| 2022-02-01 | 2022-01-28 | 4 | Sinclair Andrew See footnotes | SRRA | Common Stock, $0.001 par value | I | 13.2000 | 287,471 | 3,795 | 1,164,127 | ||||
| 2022-02-01 | 2022-01-31 | 4 | Abingworth LLP | SRRA | Common Stock, $0.001 par value | I | 27.0000 | 150,000 | 4,050 | 1,314,127 | ||||
| 2022-02-01 | 2022-01-28 | 4 | Abingworth LLP | SRRA | Series B Warrants (right to buy) | I | 13.20 | -287,471 | 0 | |||||
| 2022-02-01 | 2022-01-28 | 4 | Abingworth LLP | SRRA | Common Stock, $0.001 par value | I | 13.2000 | 287,471 | 3,795 | 1,164,127 | ||||
| 2022-01-31 | 2022-01-31 | 4 | Vivo Opportunity, LLC By Vivo Opportunity Fund, L.P. | SRRA | Common Stock | I | 27.0000 | 800,000 | 21,600 | 2,735,853 | ||||
| 2022-01-31 | 2022-01-31 | 4 | Aggarwal Gaurav By Vivo Opportunity Fund, L.P. | SRRA | Common Stock | I | 27.0000 | 800,000 | 21,600 | 2,735,853 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Ashiya Mona See footnotes | SRRA | Series B Warrants | I | 13.20 | -56,244 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Ashiya Mona See footnotes | SRRA | Series B Warrants | I | 13.20 | -56,244 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Ashiya Mona See footnotes | SRRA | Series B Warrants | I | 13.20 | -374,962 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Ashiya Mona See footnotes (4), | SRRA | Common Stock | I | 13.2000 | 56,244 | 742 | 226,704 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Ashiya Mona See footnotes | SRRA | Common Stock | I | 13.2000 | 56,244 | 742 | 226,704 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Ashiya Mona See footnotes (4), | SRRA | Common Stock | I | 13.2000 | 374,962 | 4,949 | 1,511,362 | ||||
| 2022-01-28 | 2022-01-26 | 4 | ORBIMED ADVISORS LLC | SRRA | Series B Warrants | I | 13.20 | -56,244 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | ORBIMED ADVISORS LLC | SRRA | Series B Warrants | I | 13.20 | -56,244 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | ORBIMED ADVISORS LLC | SRRA | Series B Warrants | I | 13.20 | -374,962 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | ORBIMED ADVISORS LLC | SRRA | Common Stock | I | 13.2000 | 56,244 | 742 | 226,704 | ||||
| 2022-01-28 | 2022-01-26 | 4 | ORBIMED ADVISORS LLC See footnote (4), | SRRA | Common Stock | I | 13.2000 | 56,244 | 742 | 226,704 | ||||
| 2022-01-28 | 2022-01-26 | 4 | ORBIMED ADVISORS LLC See footnote (4), | SRRA | Common Stock | I | 13.2000 | 374,962 | 4,949 | 1,511,362 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Vivo Opportunity, LLC By: Vivo Capital Fund IX, L.P. | SRRA | Series B Warrant (Right to Purchase ) | I | 13.20 | 13.2000 | -324,740 | -4,287 | 0 | |||
| 2022-01-28 | 2022-01-26 | 4 | Vivo Opportunity, LLC By: Vivo Opportunity Fund, L.P. | SRRA | Series B Warrant (Right to Purchase ) | I | 13.20 | 13.2000 | -1,455,384 | -19,211 | 0 | |||
| 2022-01-28 | 2022-01-26 | 4 | Vivo Opportunity, LLC By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Series B Warrant (Right to Purchase ) | I | 13.20 | 13.2000 | -75,749 | -1,000 | 0 | |||
| 2022-01-28 | 2022-01-26 | 4 | Vivo Opportunity, LLC By: Vivo Capital Fund IX, L.P. | SRRA | Common Stock | I | 13.2000 | 107,164 | 1,415 | 431,947 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Vivo Opportunity, LLC By: Vivo Opportunity Fund, L.P. | SRRA | Common Stock | I | 13.2000 | 480,277 | 6,340 | 1,935,853 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Vivo Opportunity, LLC By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 13.2000 | 24,996 | 330 | 161,712 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Aggarwal Gaurav By Vivo Opportunity Fund, L.P. | SRRA | Series B Warrant (Right to Purchase) | I | 13.20 | 13.2000 | -1,455,384 | -19,211 | 0 | |||
| 2022-01-28 | 2022-01-26 | 4 | Aggarwal Gaurav By Vivo Opportunity Fund, L.P. | SRRA | Common Stock | I | 13.2000 | 480,277 | 6,340 | 1,935,853 | ||||
| 2022-01-28 | 2022-01-28 | 4 | Klencke Barbara | SRRA | Stock Option (Right to Buy) | D | 12.15 | 12,250 | 12,250 | |||||
| 2022-01-28 | 2022-01-28 | 4 | Kowalski Mark | SRRA | Stock Option (Right to Buy) | D | 12.15 | 12,250 | 12,250 | |||||
| 2022-01-28 | 2022-01-28 | 4 | Norrett Kevin | SRRA | Stock Option (Right to Buy) | D | 12.15 | 12,250 | 12,250 | |||||
| 2022-01-28 | 2022-01-28 | 4 | DILLY STEPHEN GEORGE | SRRA | Stock Option (Right to Buy) | D | 12.15 | 65,000 | 65,000 | |||||
| 2022-01-28 | 2022-01-28 | 4 | Jagpal Sukhi | SRRA | Stock Option (Right to Buy) | D | 12.15 | 12,250 | 12,250 | |||||
| 2022-01-28 | 2022-01-28 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 12.15 | 12,250 | 12,250 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 13.04 | 2,000 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 29.0000 | -2,000 | -58 | 0 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Thomson Mary Christina | SRRA | Common Stock | D | 13.0400 | 2,000 | 26 | 2,000 | ||||
| 2022-01-28 | 2022-01-28 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.15 | 12,250 | 12,250 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 12.05 | 5,000 | 0 | |||||
| 2022-01-28 | 2022-01-26 | 4 | Turner William D. | SRRA | Common Stock | D | 27.0500 | -5,000 | -135 | 0 | ||||
| 2022-01-28 | 2022-01-26 | 4 | Turner William D. | SRRA | Common Stock | D | 12.0500 | 5,000 | 60 | 5,000 | ||||
| 2022-01-27 | 2022-01-25 | 4 | Longitude Capital Partners III, LLC | SRRA | Series B Warrants | I | 13.20 | 13.2000 | -1,477,125 | -19,498 | 0 | |||
| 2022-01-27 | 2022-01-25 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 13.2000 | 487,451 | 6,434 | 1,964,771 | ||||
| 2022-01-27 | 2022-01-25 | 4 | Richardson Joshua By Longitude Venture Partners III, L.P. | SRRA | Series B Warrants | I | 13.20 | 13.2000 | -1,477,125 | -19,498 | 0 | |||
| 2022-01-27 | 2022-01-25 | 4 | Richardson Joshua By Longitude Venture Partners III, L.P. | SRRA | Common Stock | I | 13.2000 | 487,451 | 6,434 | 1,964,771 | ||||
| 2021-11-24 | 2021-11-24 | 4 | Collard Craig A | SRRA | Common Stock | D | 23.0850 | 7,899 | 182 | 13,500 | ||||
| 2021-11-24 | 2021-11-23 | 4 | Collard Craig A | SRRA | Common Stock | D | 22.9450 | 5,601 | 129 | 5,601 | ||||
| 2021-11-05 | 3 | Abingworth LLP | SRRA | Common Stock, $0.001 par value | I | 878,656 | ||||||||
| 2021-06-28 | 2021-03-15 | 4 | Thomson Mary Christina | SRRA | Stock Option (Right to Buy) | D | 16.73 | 12,900 | 12,900 | |||||
| 2021-06-28 | 2020-07-28 | 4 | Thomson Mary Christina | SRRA | Stock option (right to buy) | D | 13.04 | 100,000 | 100,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Cooper Jeffrey H | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Collard Craig A | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Pelzer Robert | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Ashiya Mona | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Allen Andrew R | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Aggarwal Gaurav | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Sinclair Andrew | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-09 | 2021-06-08 | 4 | Richardson Joshua | SRRA | Stock Option (Right To Buy) | D | 18.11 | 6,000 | 6,000 | |||||
| 2021-06-04 | 2021-06-02 | 4 | Oliger Christy J. | SRRA | Stock Option (right to buy) | D | 17.76 | 18,000 | 18,000 | |||||
| 2021-06-04 | 2021-06-02 | 4 | Erbez Georgia | SRRA | Stock Option (right to buy) | D | 17.76 | 18,000 | 18,000 | |||||
| 2021-05-20 | 2021-05-19 | 4 | DILLY STEPHEN GEORGE | SRRA | Common Stock | D | 17.8300 | 5,000 | 89 | 5,000 | ||||
| 2021-03-17 | 2021-03-15 | 4 | Turner William D. | SRRA | Stock Option (Right to Buy) | D | 16.73 | 12,300 | 12,300 | |||||
| 2021-03-17 | 2021-03-15 | 4 | Thomson Christina | SRRA | Stock Option (Right to Buy) | D | 16.73 | 12,900 | 12,900 | |||||
| 2021-03-17 | 2021-03-15 | 4 | Norrett Kevin | SRRA | Stock Option (Right to Buy) | D | 16.73 | 11,700 | 11,700 | |||||
| 2021-03-17 | 2021-03-15 | 4 | Kowalski Mark | SRRA | Stock Option (Right to Buy) | D | 16.73 | 30,000 | 30,000 | |||||
| 2021-03-17 | 2021-03-15 | 4 | Jagpal Sukhi | SRRA | Stock Option (Right to Buy) | D | 16.73 | 30,000 | 30,000 | |||||
| 2021-03-17 | 2021-03-15 | 4 | Klencke Barbara | SRRA | Stock Option (Right to Buy) | D | 16.73 | 30,000 | 30,000 | |||||
| 2021-03-17 | 2021-03-15 | 4 | DILLY STEPHEN GEORGE | SRRA | Stock Option (Right to Buy) | D | 16.73 | 92,000 | 92,000 | |||||
| 2020-08-18 | 2020-08-18 | 4 | Klencke Barbara By spouse | SRRA | Common Stock | I | 12.2519 | 3,325 | 41 | 5,000 | ||||
| 2020-08-18 | 2020-08-18 | 4 | Klencke Barbara | SRRA | Common Stock | D | 12.2201 | 5,950 | 73 | 10,000 | ||||
| 2020-08-12 | 2020-08-12 | 4 | Jagpal Sukhi | SRRA | Stock Option (right to buy) | D | 12.15 | 5,887 | 5,887 | |||||
| 2020-08-12 | 2020-08-12 | 4 | Kowalski Mark | SRRA | Stock Option (right to buy) | D | 12.15 | 24,970 | 24,970 | |||||
| 2020-08-11 | 2020-08-10 | 4 | Norrett Kevin | SRRA | Stock option (right to buy) | D | 12.05 | 100,000 | 100,000 | |||||
| 2020-08-06 | 2020-08-04 | 4 | Turner William D. | SRRA | Stock option (right to buy) | D | 12.05 | 100,000 | 100,000 | |||||
| 2020-07-29 | 2020-07-28 | 4 | Thomson Christina | SRRA | Stock option (right to buy) | D | 13.04 | 100,000 | 100,000 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Aggarwal Gaurav | SRRA | Stock Option (right to buy) | D | 13.98 | 6,874 | 6,874 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Allen Andrew R | SRRA | Stock Option (right to buy) | D | 13.98 | 12,030 | 12,030 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Ashiya Mona | SRRA | Stock Option (right to buy) | D | 13.98 | 6,874 | 6,874 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Cooper Jeffrey H | SRRA | Stock Option (right to buy) | D | 13.98 | 18,061 | 18,061 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Pelzer Robert | SRRA | Stock Option (right to buy) | D | 13.98 | 16,686 | 16,686 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Richardson Joshua | SRRA | Stock Option (right to buy) | D | 13.98 | 6,874 | 6,874 | |||||
| 2020-06-10 | 2020-06-09 | 4 | Sinclair Andrew | SRRA | Stock Option (right to buy | D | 13.98 | 6,874 | 6,874 | |||||
| 2020-06-02 | 2020-06-01 | 4 | DILLY STEPHEN GEORGE | SRRA | Stock Option (right to buy) | D | 14.03 | 520,000 | 520,000 | |||||
| 2020-05-29 | 2020-05-28 | 4 | Collard Craig A | SRRA | Stock Option (right to buy) | D | 13.88 | 10,000 | 10,000 | |||||
| 2020-02-27 | 2020-02-25 | 4 | Glover Nicholas | SRRA | Stock Option (right to buy) | D | 13.31 | 359,158 | 359,158 | |||||
| 2020-02-27 | 2020-02-25 | 4 | Jagpal Sukhi | SRRA | Stock Option (right to buy) | D | 13.31 | 94,113 | 94,113 | |||||
| 2020-02-27 | 2020-02-25 | 4 | Klencke Barbara | SRRA | Stock Option (right to buy) | D | 13.31 | 167,091 | 167,091 | |||||
| 2020-02-27 | 2020-02-25 | 4 | Kowalski Mark | SRRA | Stock Option (right to buy) | D | 13.31 | 75,030 | 75,030 | |||||
| 2020-02-03 | 2020-01-29 | 4/A | Sinclair Andrew See footnotes | SRRA | Series A Convertible Voting Preferred Stock | I | -11,500 | 0 | ||||||
| 2020-02-03 | 2020-01-29 | 4/A | Sinclair Andrew See footnotes | SRRA | Common Stock | I | 871,240 | 876,656 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | ORBIMED ADVISORS LLC See footnotes | SRRA | Series A Convertible Voting Preferred Stock | I | -19,500 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | ORBIMED ADVISORS LLC See footnotes | SRRA | Common Stock | I | 1,477,320 | 1,477,320 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Aggarwal Gaurav By Vivo Opportunity Fund, LP | SRRA | Series A Convertible Voting Preferred Stock | I | -19,213 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Aggarwal Gaurav By Vivo Opportunity Fund, LP | SRRA | Common Stock | I | 1,455,576 | 1,455,576 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Ashiya Mona See footnotes | SRRA | Series A Convertible Voting Preferred Stock | I | -19,500 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Ashiya Mona See footnotes | SRRA | Common Stock | I | 1,477,320 | 1,477,320 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Richardson Joshua By Longitude Venture Partners III, L.P. | SRRA | Series A Convertible Voting Preferred Stock | I | -19,500 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Richardson Joshua By Longitude Venture Partners III, L.P. | SRRA | Common Stock | I | 1,477,320 | 1,477,320 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Longitude Capital Partners III, LLC | SRRA | Series A Convertible Voting Preferred Stock | I | -19,500 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Longitude Capital Partners III, LLC | SRRA | Common Stock | I | 1,477,320 | 1,477,320 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Vivo Opportunity, LLC By: Vivo Capital Fund IX, L.P. | SRRA | Series A Convertible Voting Preferred Stock | I | -4,287 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Vivo Opportunity, LLC By Vivo Opportunity Fund, L.P. | SRRA | Series A Convertible Voting Preferred Stock | I | -19,213 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Vivo Opportunity, LLC By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Series A Convertible Voting Preferred Stock | I | -1,000 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Vivo Opportunity, LLC By: Vivo Capital Fund IX, L.P. | SRRA | Common Stock | I | 324,783 | 324,783 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Vivo Opportunity, LLC By Vivo Opportunity Fund, L.P. | SRRA | Common Stock | I | 1,455,576 | 1,455,576 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Vivo Opportunity, LLC By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 75,759 | 136,715 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Sinclair Andrew See footnotes | SRRA | Series A Convertible Voting Preferred Stock | I | -11,500 | 0 | ||||||
| 2020-01-31 | 2020-01-29 | 4 | Sinclair Andrew See footnotes | SRRA | Common Stock | I | 871,125 | 876,542 | ||||||
| 2019-12-03 | 2019-11-29 | 4 | Sinclair Andrew | SRRA | Stock Option (right to buy) | D | 0.35 | 60,000 | 60,000 | |||||
| 2019-12-03 | 2019-11-29 | 4 | Aggarwal Gaurav | SRRA | Stock Option (Right to Buy) | D | 0.35 | 60,000 | 60,000 | |||||
| 2019-12-03 | 2019-11-29 | 4 | Ashiya Mona | SRRA | Stock Option (Right to Buy) | D | 0.35 | 60,000 | 60,000 | |||||
| 2019-12-03 | 2019-11-29 | 4 | Richardson Joshua | SRRA | Stock Option (Right to Buy) | D | 0.35 | 60,000 | 60,000 | |||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-12-02 | 3 | Vivo Ventures VII Affiliates Fund, L.P. By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. | SRRA | Common Stock | I | 4,876,540 | ||||||||
| 2019-11-26 | 3 | Sinclair Andrew See Footnotes | SRRA | Common Stock, $0.001 par value | I | 433,334 | ||||||||
| 2019-11-26 | 3 | Sinclair Andrew See Footnotes | SRRA | Common Stock, $0.001 par value | I | 433,334 | ||||||||
| 2019-11-26 | 3 | Sinclair Andrew See Footnotes | SRRA | Common Stock, $0.001 par value | I | 433,334 | ||||||||
| 2019-08-26 | 2019-08-23 | 4 | Klencke Barbara | SRRA | Common Stock | D | 0.4387 | 108,000 | 47 | 162,000 | ||||
| 2019-08-26 | 2019-08-22 | 4 | Klencke Barbara | SRRA | Common Stock | D | 0.4499 | 54,000 | 24 | 54,000 | ||||
| 2019-08-26 | 2019-08-22 | 4 | Klencke Barbara By spouse | SRRA | Common Stock | I | 0.4323 | 67,000 | 29 | 67,000 | ||||
| 2019-06-12 | 2019-06-11 | 4 | Cooper Jeffrey H | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-06-12 | 2019-06-11 | 4 | ESTES DANIEL | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-06-12 | 2019-06-11 | 4 | Nguyen Tran | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-06-12 | 2019-06-11 | 4 | ONETTO NICOLE | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-06-12 | 2019-06-11 | 4 | Parfet Donald R | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-06-12 | 2019-06-11 | 4 | Pelzer Robert | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-06-12 | 2019-06-11 | 4 | Allen Andrew R | SRRA | Stock Option (right to buy) | D | 0.66 | 30,000 | 30,000 | |||||
| 2019-03-05 | 2019-03-04 | 4 | Glover Nicholas | SRRA | Stock Option (right to buy) | D | 1.96 | 607,500 | 607,500 | |||||
| 2019-03-05 | 2019-03-04 | 4 | Hassig Christian | SRRA | Stock Option (right to buy) | D | 1.96 | 155,000 | 155,000 | |||||
| 2019-03-05 | 2019-03-04 | 4 | Jagpal Sukhi | SRRA | Stock Option (right to buy) | D | 1.96 | 200,000 | 200,000 | |||||
| 2019-03-05 | 2019-03-04 | 4 | Klencke Barbara | SRRA | Stock Option (right to buy) | D | 1.96 | 200,000 | 200,000 | |||||
| 2019-03-05 | 2019-03-04 | 4 | Kowalski Mark | SRRA | Stock Option (right to buy) | D | 1.96 | 200,000 | 200,000 | |||||
| 2018-12-11 | 2018-12-10 | 4 | Allen Andrew R | SRRA | Common Stock | D | 1.6400 | 66,000 | 108 | 66,000 | ||||
| 2018-06-14 | 2018-06-12 | 4 | Pelzer Robert | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-06-14 | 2018-06-12 | 4 | ESTES DANIEL | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-06-14 | 2018-06-12 | 4 | Allen Andrew R | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-06-14 | 2018-06-12 | 4 | Cooper Jeffrey H | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-06-14 | 2018-06-12 | 4 | Nguyen Tran | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-06-14 | 2018-06-12 | 4 | ONETTO NICOLE | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-06-14 | 2018-06-12 | 4 | Parfet Donald R | SRRA | Stock Option (right to buy) | D | 3.27 | 25,000 | 25,000 | |||||
| 2018-03-07 | 2018-03-06 | 4 | Glover Nicholas | SRRA | Stock Option (right to buy) | D | 2.36 | 562,780 | 562,780 | |||||
| 2018-03-07 | 2018-03-06 | 4 | Hassig Christian | SRRA | Stock Option (right to buy) | D | 2.36 | 205,180 | 205,180 | |||||
| 2018-03-07 | 2018-03-06 | 4 | Jagpal Sukhi | SRRA | Stock Option (right to buy) | D | 2.36 | 180,360 | 180,360 | |||||
| 2018-03-07 | 2018-03-06 | 4 | Klencke Barbara | SRRA | Stock Option (right to buy) | D | 2.36 | 180,360 | 180,360 | |||||
| 2018-03-07 | 2018-03-06 | 4 | Kowalski Mark | SRRA | Stock Option (right to buy) | D | 2.36 | 155,000 | 155,000 | |||||
| 2018-03-07 | 2018-03-06 | 4 | You Angie | SRRA | Stock Option (right to buy) | D | 2.36 | 180,360 | 180,360 | |||||
| 2018-01-08 | 2018-01-04 | 4 | Parfet Donald R | SRRA | Common Stock | D | 1,380 | 77,235 | ||||||
| 2018-01-08 | 2018-01-04 | 4 | Parfet Donald R Apjohn Ventures, LLC | SRRA | Common Stock | I | -2,760 | 0 | ||||||
| 2018-01-08 | 2018-01-04 | 4 | Parfet Donald R Apjohn Ventures, LLC | SRRA | Common Stock | I | 1,068 | 2,760 | ||||||
| 2018-01-08 | 2018-01-04 | 4 | Parfet Donald R Apjohn Ventures, LLC | SRRA | Common Stock | I | 1,692 | 1,692 | ||||||
| 2018-01-08 | 2018-01-04 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | SRRA | Common Stock | I | 3,383 | 390,913 | ||||||
| 2017-11-13 | 2017-11-10 | 4 | Allen Andrew R | SRRA | Stock Option (Right to Buy) | D | 1.92 | 50,000 | 50,000 | |||||
| 2017-10-25 | 3 | Allen Andrew R | SRRA | No securities beneficially owned. | D | 0 | ||||||||
| 2017-06-14 | 2017-06-13 | 4 | Cooper Jeffrey H | SRRA | Stock Option (right to buy) | D | 1.13 | 25,000 | 25,000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | Nguyen Tran | SRRA | Stock Option (right to buy) | D | 1.13 | 25,000 | 25,000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | ONETTO NICOLE | SRRA | Stock Option (right to buy) | D | 1.13 | 25,000 | 25,000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | Parfet Donald R | SRRA | Stock Option (right to buy) | D | 1.13 | 25,000 | 25,000 | |||||
| 2017-06-14 | 2017-06-13 | 4 | Pelzer Robert | SRRA | Stock Option (right to buy) | D | 1.13 | 25,000 | 25,000 | |||||
| 2017-05-30 | 2017-05-25 | 4 | ESTES DANIEL | SRRA | Stock Option (Right to Buy) | D | 1.20 | 50,000 | 50,000 | |||||
| 2017-04-11 | 3 | ESTES DANIEL | SRRA | No securities beneficially owned | D | 0 | ||||||||
| 2017-03-09 | 2017-03-08 | 4 | You Angie | SRRA | Common Stock | D | 1.4300 | 30,000 | 43 | 133,252 | ||||
| 2017-03-08 | 2017-03-06 | 4 | You Angie | SRRA | Stock Option (right to buy) | D | 1.45 | 70,000 | 70,000 | |||||
| 2017-03-08 | 2017-03-06 | 4 | Jagpal Sukhi | SRRA | Stock Option (right to buy) | D | 1.45 | 70,000 | 70,000 | |||||
| 2017-03-08 | 2017-03-06 | 4 | Klencke Barbara | SRRA | Stock Option (right to buy) | D | 1.45 | 70,000 | 70,000 | |||||
| 2017-03-08 | 2017-03-06 | 4 | Glover Nicholas | SRRA | Stock Option (right to buy) | D | 1.45 | 195,000 | 195,000 | |||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 14,038,047 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-24 | 3 | Heron Patrick J | SRRA | Common Stock | D | 10,298,316 | ||||||||
| 2017-02-16 | 2017-02-14 | 4 | Topper James N By Frazier Life Sciences VIII, L.P. | SRRA | Common Stock | I | 1.3500 | 5,925,926 | 8,000 | 5,925,926 | ||||
| 2017-01-04 | 3 | Kowalski Mark | DNAI | No securities beneficially held | D | 0 | ||||||||
| 2017-01-04 | 2017-01-03 | 4 | Kowalski Mark | DNAI | Stock Option (right to buy Class A Common Stock) | D | 1.54 | 300,000 | 300,000 | |||||
| 2016-11-10 | 2016-11-08 | 4 | Parfet Donald R | DNAI | Common Stock | D | 2,403 | 75,855 | ||||||
| 2016-11-10 | 2016-11-08 | 4 | Parfet Donald R Apjohn Ventures, LLC | DNAI | Common Stock | I | -4,806 | 0 | ||||||
| 2016-11-10 | 2016-11-08 | 4 | Parfet Donald R Apjohn Ventures, LLC | DNAI | Common Stock | I | 1,423 | 4,806 | ||||||
| 2016-11-10 | 2016-11-08 | 4 | Parfet Donald R Apjohn Ventures, LLC | DNAI | Common Stock | I | 3,383 | 3,383 | ||||||
| 2016-11-10 | 2016-11-08 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Common Stock | I | 6,767 | 387,530 | ||||||
| 2016-10-04 | 2016-09-30 | 4 | Jagpal Sukhi | DNAI | Stock Option (right to buy) | D | 1.82 | 168,000 | 168,000 | |||||
| 2016-10-04 | 2016-09-30 | 4 | Glover Nicholas | DNAI | Stock Option (right to buy) | D | 1.82 | 500,000 | 500,000 | |||||
| 2016-10-04 | 2016-09-30 | 4 | Klencke Barbara | DNAI | Stock Option (right to buy) | D | 1.82 | 456,000 | 456,000 | |||||
| 2016-10-04 | 2016-09-30 | 4 | You Angie | DNAI | Stock Option (right to buy) | D | 1.82 | 200,000 | 200,000 | |||||
| 2016-09-30 | 2016-09-29 | 4 | Parfet Donald R | DNAI | Common Stock | D | 1,202 | 73,452 | ||||||
| 2016-09-30 | 2016-09-29 | 4 | Parfet Donald R By Apjohn Ventures, LLC | DNAI | Common Stock | I | -2,403 | 0 | ||||||
| 2016-09-30 | 2016-09-29 | 4 | Parfet Donald R By Apjohn Ventures, LLC | DNAI | Common Stock | I | 711 | 2,403 | ||||||
| 2016-09-30 | 2016-09-29 | 4 | Parfet Donald R By Apjohn Ventures, LLC | DNAI | Common Stock | I | 1,692 | 1,692 | ||||||
| 2016-09-30 | 2016-09-29 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Common Stock | I | 3,384 | 380,763 | ||||||
| 2016-06-20 | 2016-06-16 | 4 | ONETTO NICOLE | DNAI | Stock Option (right to buy) | D | 2.06 | 38,835 | 38,835 | |||||
| 2016-06-20 | 2016-06-16 | 4 | Pelzer Robert | DNAI | Stock Option (right to buy) | D | 2.06 | 38,835 | 38,835 | |||||
| 2016-06-20 | 2016-06-16 | 4 | Parfet Donald R | DNAI | Stock Option (right to buy) | D | 2.06 | 38,835 | 38,835 | |||||
| 2016-06-20 | 2016-06-16 | 4 | Topper James N | DNAI | Stock Option (right to buy) | D | 2.06 | 38,835 | 38,835 | |||||
| 2016-06-13 | 2016-06-09 | 4 | Cooper Jeffrey H | DNAI | Stock Option (right to buy) | D | 2.06 | 77,670 | 77,670 | |||||
| 2016-06-13 | 2016-06-09 | 4 | Nguyen Tran | DNAI | Stock Option (right to buy) | D | 2.06 | 77,670 | 77,670 | |||||
| 2016-05-17 | 2016-05-13 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Common Stock | I | 3,204 | 377,379 | ||||||
| 2016-03-24 | 3 | Nguyen Tran | DNAI | No securities beneficially held | D | 0 | ||||||||
| 2016-03-24 | 3 | Cooper Jeffrey H | DNAI | No securities beneficially held | D | 0 | ||||||||
| 2016-03-24 | 2016-03-22 | 4 | Chapman Wendy | DNAI | Stock Option (right to buy) | D | 0.97 | -3,000 | 76,248 | |||||
| 2016-03-24 | 2016-03-22 | 4 | Chapman Wendy | DNAI | Common Stock | D | 7.0078 | -3,000 | -21 | 0 | ||||
| 2016-03-24 | 2016-03-22 | 4 | Chapman Wendy | DNAI | Common Stock | D | 0.9690 | 3,000 | 3 | 3,000 | ||||
| 2016-03-10 | 2016-03-08 | 4 | Messmann Richard A | DNAI | Stock Option (right to buy) | D | 6.58 | 25,000 | 25,000 | |||||
| 2016-03-10 | 2016-03-08 | 4 | Lovejoy Chandra D | DNAI | Stock Option (right to buy) | D | 6.58 | 31,000 | 31,000 | |||||
| 2016-03-10 | 2016-03-08 | 4 | Jagpal Sukhi | DNAI | Stock Option (right to buy) | D | 6.58 | 48,750 | 48,750 | |||||
| 2016-03-10 | 2016-03-08 | 4 | Glover Nicholas | DNAI | Stock Option (right to buy) | D | 6.58 | 161,250 | 161,250 | |||||
| 2016-03-10 | 2016-03-08 | 4 | Klencke Barbara | DNAI | Stock Option (right to buy) | D | 6.58 | 82,500 | 82,500 | |||||
| 2016-03-10 | 2016-03-08 | 4 | Chapman Wendy | DNAI | Stock Option (right to buy) | D | 6.58 | 25,000 | 25,000 | |||||
| 2016-03-10 | 2016-03-08 | 4 | You Angie | DNAI | Stock Option (right to buy) | D | 6.58 | 75,000 | 75,000 | |||||
| 2016-02-24 | 2016-02-22 | 4 | Chapman Wendy | DNAI | Stock Option (right to buy) | D | 0.97 | -3,000 | 79,248 | |||||
| 2016-02-24 | 2016-02-22 | 4 | Chapman Wendy | DNAI | Common Stock | D | 7.0600 | -3,000 | -21 | 0 | ||||
| 2016-02-24 | 2016-02-22 | 4 | Chapman Wendy | DNAI | Common Stock | D | 0.9690 | 3,000 | 3 | 3,000 | ||||
| 2016-01-25 | 2016-01-22 | 4 | Chapman Wendy | DNAI | Stock Option (right to buy) | D | 0.97 | -5,000 | 82,248 | |||||
| 2016-01-25 | 2016-01-22 | 4 | Chapman Wendy | DNAI | Common Stock | D | 9.3946 | -5,000 | -47 | 0 | ||||
| 2016-01-25 | 2016-01-22 | 4 | Chapman Wendy | DNAI | Common Stock | D | 0.9690 | 5,000 | 5 | 5,000 | ||||
| 2016-01-22 | 2016-01-22 | 4 | Rodigueza Wendi | DNAI | Common Stock | D | 9.6600 | -1,000 | -10 | 156,276 | ||||
| 2016-01-22 | 2016-01-21 | 4 | Rodigueza Wendi | DNAI | Common Stock | D | 10.3230 | -1,000 | -10 | 157,276 | ||||
| 2016-01-22 | 2016-01-20 | 4 | Rodigueza Wendi | DNAI | Common Stock | D | 9.5900 | -1,000 | -10 | 158,276 | ||||
| 2016-01-19 | 2016-01-15 | 4 | Glover Nicholas | DNAI | Stock Option (right to buy) | D | 0.97 | -5,000 | 864,219 | |||||
| 2016-01-19 | 2016-01-15 | 4 | Glover Nicholas | DNAI | Common Stock | D | 10.0446 | -5,000 | -50 | 0 | ||||
| 2016-01-19 | 2016-01-15 | 4 | Glover Nicholas | DNAI | Common Stock | D | 0.9690 | 5,000 | 5 | 5,000 | ||||
| 2016-01-14 | 2016-01-12 | 4 | Lovejoy Chandra D | DNAI | Stock Option (right to buy) | D | 0.97 | -7,551 | 46,140 | |||||
| 2016-01-14 | 2016-01-12 | 4 | Lovejoy Chandra D | DNAI | Common Stock | D | 11.9282 | -5,562 | -66 | 0 | ||||
| 2016-01-14 | 2016-01-12 | 4 | Lovejoy Chandra D | DNAI | Common Stock | D | 11.0628 | -15,411 | -170 | 5,562 | ||||
| 2016-01-14 | 2016-01-12 | 4 | Lovejoy Chandra D | DNAI | Common Stock | D | 0.9690 | 7,551 | 7 | 20,973 | ||||
| 2015-12-02 | 3 | Anderson Keith Edward | DNAI | No securities are beneficially owned | D | 0 | ||||||||
| 2015-12-02 | 2015-12-01 | 4 | Anderson Keith Edward | DNAI | Stock Option (right to buy) | D | 18.33 | 100,000 | 100,000 | |||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Series D Preferred Stock | I | -287,631 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Series C Preferred Stock | I | -471,242 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Series C Preferred Stock | I | -38,824 | 471,242 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Series C Preferred Stock | I | 126,558 | 510,066 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Series C Preferred Stock Warrant (right to buy) | I | 5.2150 | -126,558 | -660 | 0 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Common Stock | I | 5.2150 | 39,889 | 208 | 798,762 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Common Stock | I | 287,631 | 758,873 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Vitangcol Alvin By Capital Midwest Fund II, L.P. | DNAI | Common Stock | I | 471,242 | 471,242 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Topper James N By Frazier Healthcare VI, L.P. | DNAI | Series D Preferred Stock | I | -1,869,606 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Topper James N By Frazier Healthcare VI, L.P. | DNAI | Common Stock | I | 17.0000 | 220,000 | 3,740 | 2,186,195 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Topper James N By Frazier Healthcare VI, L.P. | DNAI | Common Stock | I | 5.2150 | 96,589 | 504 | 1,966,195 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Topper James N By Frazier Healthcare VI, L.P. | DNAI | Common Stock | I | 1,869,606 | 1,869,606 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Thompson Peter A. See Footnotes | DNAI | Series D Preferred Stock | I | -1,725,790 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Thompson Peter A. See Footnotes | DNAI | Common Stock | I | 17.0000 | 175,000 | 2,975 | 1,989,949 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Thompson Peter A. See Footnotes | DNAI | Common Stock | I | 5.2150 | 89,159 | 465 | 1,814,949 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Thompson Peter A. See Footnotes | DNAI | Common Stock | I | 1,725,790 | 1,725,790 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Rodigueza Wendi | DNAI | Series B-1 Preferred Stock | D | -1,966 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Rodigueza Wendi | DNAI | Common Stock | D | 1,966 | 159,276 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Palmero Group LLC | DNAI | Series C Preferred Stock | I | -13,130 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Palmero Group LLC | DNAI | Series A Preferred Stock | I | -46,034 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Series B-1 Preferred Stock | I | -142,422 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Series B Preferred Stock | I | -189,933 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Series A Preferred Stock | I | -306 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Series C Preferred Stock | I | -65,938 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Series B-1 Preferred Stock | I | -121,242 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Series B Preferred Stock | I | -23,944 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By wife | DNAI | Series A Preferred Stock | I | -4,415 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series C Preferred Stock | I | -24,277 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series C Preferred Stock | I | -221 | 24,277 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series C Preferred Stock | I | 719 | 24,498 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series C Preferred Stock Warrant (right to buy) | I | 5.2150 | -719 | -4 | 0 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock | I | -516,203 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock | I | -2,941 | 516,203 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock | I | 6,711 | 519,144 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock Warrant (right to buy) | I | 7.4500 | -6,711 | -50 | 0 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock | I | -40,729 | 512,433 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R y Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock | I | 265,536 | 553,162 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B-1 Preferred Stock Warrant (right to buy) | I | 2.6080 | -265,536 | -693 | 0 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series B Preferred Stock | I | -153,485 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Series A Preferred Stock | I | -26,728 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Series D Preferred Stock | I | -11,505 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Series C Preferred Stock | I | -59,225 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Series B-1 Preferred Stock | I | -67,112 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Group, LLC | DNAI | Series A Preferred Stock | I | -307 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Palmero Group LLC | DNAI | Common Stock | I | 5.2150 | 819 | 4 | 65,779 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Palmero Group LLC | DNAI | Common Stock | I | 13,130 | 64,960 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Palmero Group LLC | DNAI | Common Stock | I | 51,830 | 51,830 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Common Stock | I | 142,422 | 353,802 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Common Stock | I | 211,036 | 211,380 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Donald R. Parfet 2006 Trust, Dated May 1, 2006 | DNAI | Common Stock | I | 344 | 344 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Common Stock | I | 5.2150 | 4,119 | 21 | 217,903 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Common Stock | I | 65,938 | 213,784 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Common Stock | I | 121,242 | 147,846 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Ann VanDeWater Parfet 2006 Revocable Trust, Dated May 5, 2006 | DNAI | Common Stock | I | 26,604 | 26,604 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By wife | DNAI | Common Stock | I | 4,970 | 4,970 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 5.2150 | 1,552 | 8 | 770,045 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 24,277 | 768,493 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 516,203 | 744,216 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 170,538 | 228,013 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 30,093 | 57,475 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Common Stock | I | 5.2150 | 4,413 | 23 | 142,255 | ||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Common Stock | I | 11,505 | 137,842 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Common Stock | I | 59,225 | 126,337 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Ventures Annex Fund LP | DNAI | Common Stock | I | 67,112 | 67,112 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | Parfet Donald R By Apjohn Group, LLC | DNAI | Common Stock | I | 345 | 589 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Series D Preferred Stock | I | -44,991 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P. | DNAI | Series D Preferred Stock | I | -2,064,308 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Common Stock | I | 17.0000 | 4,693 | 80 | 2,438,270 | ||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P. | DNAI | Common Stock | I | 17.0000 | 215,307 | 3,660 | 2,433,577 | ||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Common Stock | I | 5.2150 | 2,324 | 12 | 2,218,270 | ||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P. | DNAI | Common Stock | I | 5.2150 | 106,647 | 556 | 2,215,946 | ||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Common Stock | I | 44,991 | 2,109,299 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P. | DNAI | Common Stock | I | 2,064,308 | 2,064,308 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Series D Preferred Stock | I | -44,991 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures Fund VII, L.P. | DNAI | Series D Preferred Stock | I | -2,064,308 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Common Stock | I | 17.0000 | 4,693 | 80 | 2,438,270 | ||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures Fund VII, L.P. | DNAI | Common Stock | I | 17.0000 | 215,307 | 3,660 | 2,433,577 | ||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Common Stock | I | 5.2150 | 2,324 | 12 | 2,218,270 | ||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures Fund VII, L.P. | DNAI | Common Stock | I | 5.2150 | 106,647 | 556 | 2,215,946 | ||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures VII Affiliates Fund, L.P. | DNAI | Common Stock | I | 44,991 | 2,109,299 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | CHA ALBERT By Vivo Ventures Fund VII, L.P. | DNAI | Common Stock | I | 2,064,308 | 2,064,308 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | ORBIMED ADVISORS LLC See Footnotes | DNAI | Series D Preferred Stock | I | -1,725,790 | 0 | ||||||
| 2015-07-21 | 2015-07-21 | 4 | ORBIMED ADVISORS LLC See Footnotes | DNAI | Common Stock | I | 17.0000 | 175,000 | 2,975 | 1,989,949 | ||||
| 2015-07-21 | 2015-07-21 | 4 | ORBIMED ADVISORS LLC See Footnotes | DNAI | Common Stock | I | 5.2150 | 89,159 | 465 | 1,814,949 | ||||
| 2015-07-21 | 2015-07-21 | 4 | ORBIMED ADVISORS LLC See Footnotes | DNAI | Common Stock | I | 1,725,790 | 1,725,790 | ||||||
| 2015-07-15 | 3 | You Angie | DNAI | Common Stock | D | 206,504 | ||||||||
| 2015-07-15 | 3 | You Angie | DNAI | Common Stock | D | 206,504 | ||||||||
| 2015-07-15 | 3 | Rodigueza Wendi | DNAI | Common Stock | D | 314,620 | ||||||||
| 2015-07-15 | 3 | Rodigueza Wendi | DNAI | Common Stock | D | 314,620 | ||||||||
| 2015-07-15 | 3 | Messmann Richard A | DNAI | Common Stock | D | 80,104 | ||||||||
| 2015-07-15 | 3 | Messmann Richard A | DNAI | Common Stock | D | 80,104 | ||||||||
| 2015-07-15 | 3 | Lovejoy Chandra D | DNAI | Common Stock | D | 26,844 | ||||||||
| 2015-07-15 | 3 | Lovejoy Chandra D | DNAI | Common Stock | D | 26,844 | ||||||||
| 2015-07-15 | 3 | Parfet Donald R By Apjohn Group, LLC | DNAI | Common Stock | I | 97,718 | ||||||||
| 2015-07-15 | 3 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 124,856 | ||||||||
| 2015-07-15 | 3 | Parfet Donald R By Apjohn Ventures Fund, LP | DNAI | Common Stock | I | 124,856 | ||||||||
| 2015-07-15 | 3 | Parfet Donald R By Apjohn Group, LLC | DNAI | Common Stock | I | 97,718 | ||||||||
| 2015-07-15 | 3 | Parfet Donald R | DNAI | Common Stock | D | 167,322 | ||||||||
| 2015-07-15 | 3 | Parfet Donald R | DNAI | Common Stock | D | 167,322 |
P
非衍生或衍生证券的公开市场或私下买入
S
非衍生或衍生证券的公开市场或私下卖出
A
公司向内部人员授予、奖励或以其他方式获取证券（例如股票期权）
C
衍生工具转换
D
将证券卖出或转让回公司
F
使用从公司收到的证券的一部分来支付行使价或税务负担。
G
内部人士赠送或接收他人赠送公司股票
K
股权掉期和类似的避险交易
M
行使或转换从公司获得的衍生证券（例如期权）
V
内部人士通过Form 4自愿报告的一笔交易
J
其他（附有交易描述的脚注）
