SCPS / Scopus BioPharma Inc. - SEC备案- 年度报告、委托书

Scopus 生物制药公司
US ˙ OTCPK ˙ US8091711015

基本统计
CIK 1772028
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Scopus BioPharma Inc.
SEC Filings (Chronological Order)
本页提供了美国证券交易委员会(SEC)备案的完整、按时间顺序排列的列表,不包括我们在其他地方提供的所有权备案。
January 19, 2024 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number: 001-39788 Scopus BioPharma Inc. (Exact name of registrant as specified in i

August 18, 2023 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 SCOPUS BIOPHARMA INC.

August 18, 2023 EX-3.1

Certificate of Amendment for Amended and Restated Certificate of Incorporation of Scopus BioPharma Inc.

Exhibit 3.1 Delaware The First State Page 1 6384624 8100 Authentication: 203959432 SR# 20233239038 Date: 08-14-23 You may verify this certificate online at corp.delaware.gov/authver.shtml I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE CERTIFICATE OF AMENDMENT OF “SCOPUS BIOPHARMA INC.”, FILED IN THIS OFFICE ON TH

August 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period ended from to Commission File Numb

August 11, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2023 SCOPUS BIOPHARMA INC.

July 21, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) x Definitive Proxy Statem

June 28, 2023 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: x Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ¨ Definitive Proxy Statem

May 12, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period ended from to Commission File Num

April 28, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (mark one) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRAN

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (mark one) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-

April 14, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (mark one) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUA

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (mark one) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39

April 14, 2023 EX-10.26

Form of Subscription Agreement for Shares of Common Stock

Exhibit 10.26 Name of Investor: For U.S. Investors: Social Security Number or EIN: SUBSCRIPTION AGREEMENT FOR SHARES OF COMMON STOCK Scopus BioPharma Inc., a Delaware corporation (the “Company”), and the undersigned investor (the “Investor”) hereby agree as follows: 1.Subscription for Shares. The Investor hereby subscribes for and agrees to purchase shares of common stock, par value $0.001 per sha

April 14, 2023 EX-10.25

Form of Exchange Agreement

Exhibit 10.25 EXECUTION COPY EXCHANGE AGREEMENT THIS EXCHANGE AGREEMENT (this “Agreement”), dated as of , 2022, is entered into among SCOPUS BIOPHARMA INC., a Delaware corporation (“Scopus”), DUET BIOTHERAPUETICS INC., a Delaware corporation (“Duet”), and (the “Holder”). WHEREAS, Holder currently holds Series W Warrants of Scopus to purchase Series B Units of Scopus (the “Existing Warrant”); and W

March 31, 2023 NT 10-K

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING (Check One): x Form 10-K ¨ Form 20-F ¨ Form 11-K ¨ Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: December 31, 2022 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transition Report on Form 10-Q ¨ Transition Report on Form N-SAR For the Transition Period Ended: Read Instruction (on back page) Before Preparing Form.

December 16, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2022 SCOPUS BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2022 SCOPUS BIOPHARMA INC.

December 2, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 SCOPUS BIOPHARMA INC.

December 2, 2022 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

PRE 14A 1 tm2231852d1pre14a.htm PRE 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: x Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rul

November 21, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

November 15, 2022 NT 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING (Check One): ? Form 10-K ? Form 20-F ? Form 11-K x Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: September 30, 2022 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form 10-Q ? Transition Report on Form N-SAR For the Transition Period Ended: Read Instruction (on back page) Before Preparing Form.

October 20, 2022 EX-10.1

Form of Exchange Agreement

Exhibit 10.1 FORM OF EXCHANGE AGREEMENT THIS EXCHANGE AGREEMENT (this ?Agreement?), dated as of , 2022, is entered into among SCOPUS BIOPHARMA INC., a Delaware corporation (?Scopus?), DUET BIOTHERAPUETICS INC., a Delaware corporation (?Duet?), and (the ?Holder?). WHEREAS, Holder currently holds Series W Warrants of Scopus to purchase Series B Units of Scopus (the ?Existing Warrant?); and WHEREAS,

October 20, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 14, 2022 SCOPUS BIOPHARMA INC.

October 19, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 SCOPUS BIOPHARMA INC.

October 19, 2022 EX-99.1

Scopus Biopharma Completes Recapitalization Designed To Enhance Shareholder Value Warrants to Purchase Approximately 21 Million Scopus Shares Eliminated Scopus BioPharma’s Pure Play Immuno-Oncology Subsidiary, Duet BioTherapeutics, Independently Valu

Exhibit 99.1 Scopus Biopharma Completes Recapitalization Designed To Enhance Shareholder Value Warrants to Purchase Approximately 21 Million Scopus Shares Eliminated Scopus BioPharma?s Pure Play Immuno-Oncology Subsidiary, Duet BioTherapeutics, Independently Valued at $25 Million Scopus Maintains Approximately 90% Ownership Stake in Duet Duet Being Positioned to Go Public in 2023 New York, New Yor

October 7, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 4, 2022 SCOPUS BIOPHARMA INC.

September 16, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2022 SCOPUS BIOPHARMA INC.

September 2, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 31, 2022 SCOPUS BIOPHARMA INC.

August 15, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

July 15, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 13, 2022 SCOPUS BIOPHARMA INC.

May 27, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2022 SCOPUS BIOPHARMA INC.

May 20, 2022 EX-99.1

Sydney, May 19, 2022

Exhibit 99.1 Sydney, May 19, 2022 Scopus Biopharma Inc. Attn. Joshua R. Lamstein: I, Paul Hopper, submit this letter as official notification of my intent to resign from my position as Director of Scopus Biopharma Inc. (?the Company?), effective immediately. I was certified as a Board member in June 2020, when the Company acquired Bioscience Oncology?a company that I founded, and for which Scopus

May 20, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 18, 2022 SCOPUS BIOPHARMA INC.

May 19, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

May 13, 2022 EX-99.1

Ashish Sanghrajka

Exhibit 99.1 Ashish Sanghrajka New York, NY May 11, 2022 To: Scopus Biopharma Inc. Attn. Joshua R. Lamstein: I, Ashish Sanghrajka, submit this letter as official notification of my intent to resign from my position as Director of Scopus Biopharma Inc. (the ?Company?), effective immediately. Throughout my time as a Director, former President, and former CFO of the Company, Ira S. Greenspan, Joshua

May 13, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2022 SCOPUS BIOPHARMA INC.

May 13, 2022 NT 10-Q

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING (Check One): ? Form 10-K ? Form 20-F ? Form 11-K x Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: March 31, 2022 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form 10-Q ? Transition Report on Form N-SAR For the Transition Period Ended: Read Instruction (on back page) Before Preparing Form.

May 4, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 28, 2022 SCOPUS BIOPHARMA INC.

May 2, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (mark one) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ¨ TRAN

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (mark one) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-

April 29, 2022 EX-99.1

April 26, 2022

Exhibit 99.1 April 26, 2022 Scopus Biopharma Inc. Attn. Joshua R. Lamstein I, Joshua Levine, submit this letter as official notification of my intent to resign from my position as director of Scopus Biopharma Inc. (the ?Company?), effective immediately. I was certified as a board member in January 2022, and was excited to take on the responsibilities of the position. Unfortunately, it became appar

April 29, 2022 EX-99.2

Scopus Biopharma Inc

Exhibit 99.2 Scopus Biopharma Inc. April 26, 2022 Attn. Joshua R. Lamstein I, Mordechai Hacham, submit this letter as official notification of my intent to resign from my position as director of Scopus Biopharma Inc. (the ?Company?), effective immediately. I was certified as a board member in January 2022 and was excited to take on the responsibilities of the position. Unfortunately, it became app

April 29, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 26, 2022 SCOPUS BIOPHARMA INC.

April 15, 2022 EX-21.1

List of Subsidiaries

Exhibit 21.1 Subsidiaries of Registrant Vital Spark, Inc. Delaware Scopus BioPharma Israel Ltd. Israel Duet BioTherapeutics Inc. Delaware Bioscience Oncology Pty Ltd Australia ?

April 15, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (mark one) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ☐ TRANSITION REPORT PURSUA

Table of Contents ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

April 8, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 4, 2022 SCOPUS BIOPHARMA INC.

April 1, 2022 NT 10-K

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 Commission File Number 001-39788 NOTIFICATION OF LATE FILING (Check One): x Form 10-K ? Form 20-F ? Form 11-K ? Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: December 31, 2021 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form 10-Q ? Transition Report on Form N-SAR For the Transition Period Ended: Read Instruction (on back page) Before Preparing Form.

March 24, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2022 SCOPUS BIOPHARMA INC.

March 23, 2022 EX-99.1

TLR9 activation and STAT3 inhibition: a bifunctional approach to immuno - oncology March 2022 STING & TLR - Targeting Therapies Summit 2022

Exhibit 99.1 TLR9 activation and STAT3 inhibition: a bifunctional approach to immuno - oncology March 2022 STING & TLR - Targeting Therapies Summit 2022 Investment highlights 2 Duet?s platform provides a unique approach to treating hematological malignancies and solid tumor cancers Strong IP position Duet has 4 issued patents and 4 submitted PCT applications that cover the technologies that make u

March 23, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 23, 2022 SCOPUS BIOPHARMA INC.

March 4, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2022 SCOPUS BIOPHARMA INC.

February 25, 2022 8-K

Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2022 SCOPUS BIOPHARMA INC.

February 18, 2022 EX-16.1

Letter from Citrin Cooperman & Company, LLP to the Securities and Exchange Commission dated February 18, 2022

Exhibit 16.1 February 18, 2022 Office of the Chief Accountant Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Dear Sir or Madam: We have read Item 4.01 of Form 8-K dated February 18, 2022, of Scopus BioPharma Inc. and Subsidiaries and agree with the statements contained in paragraphs 1, 2, 3 and 4 therein. We have no basis to agree or disagree with other statements of

February 18, 2022 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 16, 2022 SCOPUS BIOPHARMA INC.

February 15, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including additional amendments thereto) with respect to the shares of Common Stock, $0.001 par value, of Scopus BioPharma Inc. This Joint Filing Agreement shall be

February 15, 2022 SC 13G

SCPS / Scopus Biopharma Inc / ARMISTICE CAPITAL, LLC - SC 13G Passive Investment

SC 13G 1 d306698dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Scopus BioPharma Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 809171101 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate b

January 20, 2022 EX-10.2

Form of Amendment to the Registration Rights Agreement, dated as of January 14, 2022, by and among Scopus BioPharma Inc. and the investors named therein

Exhibit 10.2 AMENDMENT NO. 1 TO REGISTRATION RIGHTS AGREEMENT AMENDMENT NO. 1 TO REGISTRATION RIGHTS AGREEMENT, dated as of January 14, 2022 (this ?Amendment?), among SCOPUS BIOPHARMA INC., a Delaware corporation (the ?Company?) and the holder signatory hereto (the ?Holder?). Capitalized terms used and not otherwise defined herein shall have the meanings set forth in the Registration Rights Agreem

January 20, 2022 8-K

Entry into a Material Definitive Agreement, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2022 SCOPUS BIOPHARMA INC.

January 20, 2022 424B2

PROSPECTUS 3,000,000 shares of Common Stock 3,000,000 shares of Common Stock issuable upon the exercise of additional investment options

Filed Pursuant to Rule 424(b)(2) Registration No. 333-261991 PROSPECTUS 3,000,000 shares of Common Stock 3,000,000 shares of Common Stock issuable upon the exercise of additional investment options This prospectus covers the offer and resale by the selling stockholders identified in this prospectus of up to an aggregate of 6,000,000 shares of our common stock, consisting of (i) 3,000,000 shares of

January 20, 2022 EX-10.1

Form of Amendment to the Securities Purchase Agreement, dated as of January 14, 2022, by and among Scopus BioPharma Inc. and the investors named therein

Exhibit 10.1 AMENDMENT NO. 1 TO SECURITIES PURCHASE AGREEMENT AMENDMENT NO. 1 TO SECURITIES PURCHASE AGREEMENT, dated as of January 14, 2022 (this ?Amendment?), among SCOPUS BIOPHARMA INC., a Delaware corporation (the ?Company?) and the Purchaser signatory hereto. Capitalized terms used and not otherwise defined herein shall have the meanings set forth in the Purchase Agreement, as defined herein.

January 13, 2022 CORRESP

VIA EDGAR

VIA EDGAR January 13, 2022 Division of Corporation Finance Office of Life Sciences United States Securities and Exchange Commission 100 F Street, N.

January 10, 2022 8-K/A

Other Events, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 20, 2021 SCOPUS BIOPHARMA INC.

January 5, 2022 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant x Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

January 4, 2022 S-3

As filed with the Securities and Exchange Commission on January 3, 2022

As filed with the Securities and Exchange Commission on January 3, 2022 Registration Statement No.

December 27, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 20, 2021 SCOPUS BIOPHARMA INC.

December 22, 2021 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant x Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 17, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 17, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A 1 tm2135743d1defa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by R

December 16, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant?????????? ??? ????Filed by a Party other than the Registrant?? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

December 7, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 7, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 2, 2021 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant x Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

November 26, 2021 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 21, 2021 SCOPUS BIOPHARMA INC.

November 26, 2021 SC 13D

SCPS / Scopus Biopharma Inc / HCFP/Capital Partners 18B-1 LLC - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.)* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) 809171101 (CUSIP Number) Joshua R. Lamstein 420 Lexington Avenue, Suite 300 New York, New York 10170 Phone: (212) 479-2513 (Name, Address and Telephone Number of Person Auth

November 26, 2021 EX-10.2

Form of Registration Rights Agreement, dated as of November 21, 2021

Exhibit 10.2 EXHIBIT B REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of November 21, 2021, between Scopus Biopharma, Inc., a Delaware corporation (the ?Company?), and each of the several purchasers signatory hereto (each such purchaser, a ?Purchaser? and, collectively, the ?Purchasers?). This Agreement is made pursuant to the Securi

November 26, 2021 EX-10.1

Form of Securities Purchase Agreement, dated as of November 21, 2021

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of November 21, 2021 between Scopus Biopharma, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively, the ?Purchasers?). WHEREAS, subject to the terms and conditio

November 26, 2021 SC 13D/A

SCPS / Scopus Biopharma Inc / HCFP/Capital Partners 18B-2 LLC - SCHEDULE 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock Title of Class of Securities) 809171101 (CUSIP Number) Joshua R. Lamstein 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 (Name, Address and Telephone Number of Person Authoriz

November 26, 2021 EX-99.2

To Whom It May Concern:

Exhibit 99.2 TO: The Purchasers of Scopus BioPharma Inc. (the ?Company?), Common Stock and Warrants To Whom It May Concern: This letter agreement (the ?Agreement?) will confirm my agreement to vote all shares of Scopus BioPharma Inc. voting stock over which the undersigned has voting control in favor of any resolution presented to the shareholders of the Company to approve the increase in the auth

November 26, 2021 EX-99.1

Joint Filing Agreement, dated November 26, 2021 by and among HCFP/Capital Partners 18B-1 LLC, Ira Scott Greenspan, and Joshua R. Lamstein (filed herewith).

Exhibit 99.1 AGREEMENT AS TO A JOINT FILING OF SCHEDULE 13D In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree that (1) only one statement containing the information required by Schedule 13D and any further amendments thereto need to be filed with respect to the beneficial ownership be each of the undersigned of shares of common stock of S

November 26, 2021 EX-99.1

AGREEMENT AS TO A JOINT FILING OF SCHEDULE 13D

Exhibit 99.1 AGREEMENT AS TO A JOINT FILING OF SCHEDULE 13D In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree that (1) only one statement containing the information required by Schedule 13D and any further amendments thereto need to be filed with respect to the beneficial ownership by each of the undersigned of shares of common stock of S

November 26, 2021 EX-99.1

AGREEMENT AS TO A JOINT FILING OF SCHEDULE 13D

Exhibit 99.1 AGREEMENT AS TO A JOINT FILING OF SCHEDULE 13D In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree that (1) only one statement containing the information required by Schedule 13D and any further amendments thereto need to be filed with respect to the beneficial ownership by each of the undersigned of shares of common stock of S

November 26, 2021 SC 13D/A

SCPS / Scopus Biopharma Inc / SCPS/Strategic Capital Partners LLC - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) 809171101 (CUSIP Number) Joshua R. Lamstein 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 (Name, Address and Telephone Number of Person Authori

November 26, 2021 EX-4.2

Form of Series B Additional Investment Option

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

November 26, 2021 EX-10.3

Warrant Contribution Agreement, dated as of November 21, 2021

Exhibit 10.3 WARRANT CONTRIBUTION AGREEMENT THIS WARRANT CONTRIBUTION AGREEMENT (this ?Agreement?) is made as of this 23rd day of November, 2021, by and between Scopus BioPharma Inc., a Delaware corporation (the ?Company?) and HCFP/Capital Partners 18B-2 LLC, a Delaware limited liability company (?HCFP?). WHEREAS, in connection with the transactions contemplated by that certain Securities Purchase

November 26, 2021 EX-99.2

To Whom It May Concern:

Exhibit 99.2 TO: The Purchasers of Scopus BioPharma Inc. (the ?Company?), Common Stock and Warrants To Whom It May Concern: This letter agreement (the ?Agreement?) will confirm my agreement to vote all shares of Scopus BioPharma Inc. voting stock over which the undersigned has voting control in favor of any resolution presented to the shareholders of the Company to approve the increase in the auth

November 26, 2021 EX-4.1

Form of Series A Additional Investment Option

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

November 26, 2021 EX-99.2

To Whom It May Concern:

Exhibit 99.2 TO: The Purchasers of Scopus BioPharma Inc. (the “Company”), Common Stock and Warrants To Whom It May Concern: This letter agreement (the “Agreement”) will confirm my agreement to vote all shares of Scopus BioPharma Inc. voting stock over which the undersigned has voting control in favor of any resolution presented to the shareholders of the Company to approve the increase in the auth

November 26, 2021 EX-4.3

Form of Placement Agent Additional Investment Option

Exhibit 4.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

November 26, 2021 EX-99.1

Scopus BioPharma Announces $9.75 Million Private Placement Priced At-The-Market

Exhibit 99.1 Scopus BioPharma Announces $9.75 Million Private Placement Priced At-The-Market New York, New York, November 22, 2021 ? Scopus BioPharma Inc. (Nasdaq: ?SCPS?), a clinical-stage biopharmaceutical company developing transformational therapeutics for serious diseases with significant unmet medical need, today announced it has entered into securities purchase agreements with certain insti

November 24, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? Filed by the Registrant ? ? ? Filed by a Party other than the Registrant ? ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? ? Definiti

November 12, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

November 8, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

October 28, 2021 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant x Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

October 27, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

October 12, 2021 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? ? Definitive Proxy

October 8, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

October 6, 2021 DEFC14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549? ? SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by Rule

September 30, 2021 EX-10.21

Indemnification Agreement, dated as of September 26, 2021

Exhibit 10.21 Execution Copy INDEMNIFICATION AGREEMENT THIS INDEMNIFICATION AGREEMENT (this ?Agreement?) is made as of September 26, 2021 (the ?Effective Date?), by and among HCFP/Portfolio Services LLC, a Delaware limited liability company (?HCFP?), Scopus BioPharma Inc., a Delaware corporation (the ?Company?), and HCFP?s principals, Ira Greenspan, Joshua Lamstein, and Robert Gibson (together, th

September 30, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2021 SCOPUS BIOPHARMA INC.

September 30, 2021 PRRN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment no. 1)

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549? ? SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment no. 1) ? Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as

September 28, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

September 17, 2021 PREC14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant x Check the appropriate box: x Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive

September 16, 2021 DEFC14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549? ? SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? Filed by the Registrant ? ? Filed by a Party other than the Registrant ? ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by R

September 13, 2021 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2021 SCOPUS BIOPHARMA INC.

September 13, 2021 EX-99.1

Launch of Duet Therapeutics, a wholly - owned immuno - oncology subsidiary of Scopus BioPharma September 2021

Exhibit 99.1 Launch of Duet Therapeutics, a wholly - owned immuno - oncology subsidiary of Scopus BioPharma September 2021 DISCLAIMERS This presentation contains forward - looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 . All statements regarding Scopus BioPharma Inc . , ?Scopus? or the ?Company? that are not historical fact, including, but not limited

August 26, 2021 PREC14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: x Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive

August 13, 2021 EX-10.18

Stock Exchange Agreement, dated June 25, 2021

Exhibit 10.18 STOCK EXCHANGE AGREEMENT by and among SCOPUS BIOPHARMA INC., and THE SELLERS PARTY HERETO ? ? ? ? ? STOCK EXCHANGE AGREEMENT This STOCK EXCHANGE AGREEMENT (this ?Agreement?) is entered into by and among (i) Scopus BioPharma Inc., a Delaware corporation (?Scopus?) and (ii) the individual signatories to this Agreement, each of whom is individually referred to as a ?Seller? and collecti

August 13, 2021 EX-10.20

Decoy Exclusive License Agreement, dated June 25, 2021

Exhibit 10.20 ? Information has been excluded that is not material and which the company treats as confidential. ? CONFIDENTIAL EXECUTION VERSION ? EXCLUSIVE LICENSE AGREEMENT ? THIS EXCLUSIVE LICENSE AGREEMENT (the ?Agreement?) is made and entered into as of the 25 day of June, 2021 (the ?Effective Date?) by and Olimmune, Inc., a Delaware corporation having its principal place of business at 1021

August 13, 2021 EX-10.19

ASO Exclusive License Agreement, dated June 25, 2021

? Exhibit 10.19 ? Information has been excluded that is not material and which the company treats as confidential. ? ? ? CONFIDENTIAL EXECUTION VERSION ? EXCLUSIVE LICENSE AGREEMENT ? THIS EXCLUSIVE LICENSE AGREEMENT (the ?Agreement?) is made and entered into as of the 25th day of June, 2021 (the ?Effective Date?) by and Olimmune, Inc., a Delaware corporation having its principal place of business

August 13, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

August 12, 2021 SC 13D

SCPS / Scopus Biopharma Inc / HCFP/Capital Partners 18B-2 LLC - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.)* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) 809171101 (CUSIP Number) Joshua R. Lamstein, 420 Lexington Avenue, Suite 300 New York, New York 10170/ Phone: (212) 479-2513 (Name, Address and Telephone Number of Person Au

August 12, 2021 SC 13D

SCPS / Scopus Biopharma Inc / SCPS/Strategic Capital Partners LLC - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.)* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) 809171101 (CUSIP Number) Joshua R. Lamstein, 420 Lexington Avenue, Suite 300 New York, New York 10170/ Phone: (212) 479-2513 (Name, Address and Telephone Number of Person Au

July 13, 2021 SC 13G

SCPS / Scopus Biopharma Inc / Kortylewski Marcin - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) 809171101 (CUSIP Number) June 25, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ?

July 9, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 2, 2021 SCOPUS BIOPHARMA INC.

July 1, 2021 EX-99.1

Scopus BioPharma Expands Immunotherapy Pipeline with Acquisition of Olimmune Transaction Creates Global Leader in Oligonucleotide Cancer Therapeutics Combined Assets Target Broad Range of Hematological Malignancies and Solid Tumors

Exhibit 99.1 Scopus BioPharma Expands Immunotherapy Pipeline with Acquisition of Olimmune Transaction Creates Global Leader in Oligonucleotide Cancer Therapeutics Combined Assets Target Broad Range of Hematological Malignancies and Solid Tumors New York, New York, June 30, 2021 ? Scopus BioPharma Inc. (Nasdaq: ?SCPS?), a clinical-stage biopharmaceutical company developing transformational therapeu

July 1, 2021 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2021 SCOPUS BIOPHARMA INC.

June 1, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

May 27, 2021 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant x Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period ended from to Commission File Number: 001-39788 SCO

May 12, 2021 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment no. 1)* SCOPUS BIOPHARMA INC. (Name of Company) Common Stock, par value $0.001 per share (Title of Class of Se

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment no. 1)* SCOPUS BIOPHARMA INC. (Name of Company) Common Stock, par value $0.001 per share (Title of Class of Securities) 809171101 (CUSIP Number of Class of Securities) Anna T. Pinedo Mayer Brown LLP 1221 Avenue of the Americas New York, NY 10020 (212) 506-2275

April 29, 2021 10-K/A

Annual Report - FORM 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) (mark one) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-

April 7, 2021 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment no. __)* SCOPUS BIOPHARMA INC. (Name of Company) Common Stock, par value $0.001 per share (Title of Class of Sec

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment no. )* SCOPUS BIOPHARMA INC. (Name of Company) Common Stock, par value $0.001 per share (Title of Class of Securities) 809171101 (CUSIP Number of Class of Securities) Anna T. Pinedo Mayer Brown LLP 1221 Avenue of the Americas New York, NY 10020 (212) 506-2275 (N

March 29, 2021 EX-4.9

Description of securities registered under Section 12 of the Exchange Act of 1934

EXHIBIT 4.9 DESCRIPTION OF REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 Set forth below is the description of the securities of Scopus BioPharma Inc. (the ?Company?) currently registered under Section 12 of the Securities Exchange Act of 1934 (the ?Exchange Act?). The following description summarizes the most important terms of these securities.

March 29, 2021 EX-3.2

Amended and Restated By-laws of the Registrant

EXHIBIT 3.2 SCOPUS BIOPHARMA INC. AMENDED AND RESTATED BY-LAWS ARTICLE I Offices Section 1.01 Registered Office. The registered office of Scopus BioPharma Inc. (the "Corporation") will be fixed in the Certificate of Incorporation of the Corporation (the "Certificate of Incorporation"). Section 1.02 Other Offices. The Corporation may have other offices, both within and without the State of Delaware

March 29, 2021 10-K

Annual Report - FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (mark one) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39788 SCOPUS BIOPHAR

March 19, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2021 SCOPUS BIOPHARMA INC.

March 19, 2021 EX-99.1

Scopus BioPharma Finalizes Arrangements for Submission of IND Package Submission to FDA Expected in Q2 2021

Exhibit 99.1 Scopus BioPharma Finalizes Arrangements for Submission of IND Package Submission to FDA Expected in Q2 2021 New York, New York, March 15, 2021 ? Scopus BioPharma Inc. (Nasdaq: ?SCPS?) today announced the finalization of arrangements for the completion of the investigational new drug (?IND?) package for the company?s lead drug candidate and its submission to the United States Food and

February 26, 2021 10-Q/A

Quarterly Report - FORM 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q/A (Amendment No. 1) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended: September 30, 2020 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-39788 SCOPUS BIOPHARMA INC (Exact name

February 16, 2021 SC 13G

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 31, 2020 (Da

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SCOPUS BIOPHARMA INC. (Name of Issuer) Common Stock (Title of Class of Securities) 809171101 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is file

February 1, 2021 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 27, 2021 SCOPUS BIOPHARMA INC.

February 1, 2021 SC TO-C

- FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 27, 2021 SCOPUS BIOPHARMA INC.

February 1, 2021 EX-99.1

Scopus BioPharma Announces Exchange Offer Exchange Would Provide Incentives for Long-Term Ownership by Existing and Prospective New Investors

EX-99.1 2 tm214860d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Scopus BioPharma Announces Exchange Offer Exchange Would Provide Incentives for Long-Term Ownership by Existing and Prospective New Investors New York, New York, January 27, 2021 – Scopus BioPharma Inc. (Nasdaq: “SCPS”) today announced that it intends to effectuate an exchange offer (the “Exchange”) pursuant to which Scopus BioPharma common

February 1, 2021 EX-99.1

Press Release dated January 27, 2021

Exhibit 99.1 Scopus BioPharma Announces Exchange Offer Exchange Would Provide Incentives for Long-Term Ownership by Existing and Prospective New Investors New York, New York, January 27, 2021 – Scopus BioPharma Inc. (Nasdaq: “SCPS”) today announced that it intends to effectuate an exchange offer (the “Exchange”) pursuant to which Scopus BioPharma common stock would become exchangeable for units (t

January 28, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant

Exhibit 3.1 Delaware Page 1 The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE RESTATED CERTIFICATE OF “PROJECT18 INC.”, CHANGING ITS NAME FROM “PROJECT18 INC.” TO “SCOPUS BIOPHARMA INC.”, FILED IN THIS OFFICE ON THE ELEVENTH DAY OF DECEMBER, A.D. 2017, AT 5:50 O’ CLOCK P.M. /s/ Jeffrey W. Bullock Jef

January 28, 2021 EX-3.2

Amended and Restated By-laws of the Registrant

Exhibit 3.2 SCOPUS BIOPHARMA INC. AMENDED AND RESTATED BY-LAWS ARTICLE I Offices Section 1.01 Registered Office. The registered office of Scopus BioPharma Inc. (the "Corporation") will be fixed in the Certificate of Incorporation of the Corporation (the "Certificate of Incorporation"). Section 1.02 Other Offices. The Corporation may have other offices, both within and without the State of Delaware

January 28, 2021 EX-10.1

2018 Equity Incentive Plan*

Exhibit 10.1 scopus biopharma INC. 2018 EQUITY INCENTIVE PLAN 1. Purpose. The purpose of this 2018 EQUITY INCENTIVE PLAN (the “Plan”) is to assist Scopus BioPharma Inc., a Delaware corporation (the “Company”), in attracting, motivating, retaining and rewarding high-quality executives and other employees, officers, directors, consultants and other persons who provide services to the Company by enab

January 28, 2021 10-Q

Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended: September 30, 2020 ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-39788 SCOPUS BIOPHARMA INC (Exact name of registrant as sp

January 28, 2021 253G1

- 253G1

TABLE OF CONTENTS  Filed Pursuant to Rule 253(g)(1)  File No. 024-11228 Offering Circular 1,000,000 Shares Common Stock We are offering 1,000,000 shares of our common stock. The public offering price is $9.00 per share. Our common stock is listed on The Nasdaq Global Market under the symbol “SCPS”. On January 25, 2021, the last sale price of our common stock on Nasdaq was $12.09 per share. We are

January 26, 2021 CORRESP

-

Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, NY 10170 January 26, 2021 Ms. Margaret Schwartz Division of Corporation Finance Office of Life Sciences Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Re: Scopus BioPharma Inc. Post Qualification Amendment No. 3 to Form 1-A Filed: January 26, 2021 File No.: 024-11228 Acceleration Request Requested Date: Jan

January 26, 2021 EX1A-1 UNDR AGMT

- EX1A-1 UNDR AGMT

EX1A-1 UNDR AGMT 3 tm211851d5ex1-1.htm EX1A-1 UNDR AGMT Exhibit 1.1 UNDERWRITING AGREEMENT [●], 2021 The Benchmark Company, LLC 150 East 58th St., 17th Floor New York, NY 10155 As Representative of the several Underwriters named on Schedule 1 attached hereto Ladies and Gentlemen: The undersigned, Scopus BioPharma Inc., a Delaware corporation (the “Company”), hereby confirms its agreement (this “Ag

January 26, 2021 EX1A-3 HLDRS RTS

Form of Underwriter Share Purchase Option

Exhibit 3.10 THE REGISTERED HOLDER OF THIS PURCHASE OPTION BY ITS ACCEPTANCE HEREOF, AGREES THAT THIS PURCHASE OPTION SHALL NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, OR HYPOTHECATED, OR BE THE SUBJECT OF ANY HEDGING, SHORT SALE, DERIVATIVE, PUT, OR CALL TRANSACTION THAT WOULD RESULT IN THE EFFECTIVE ECONOMIC DISPOSITION OF THE SECURITIES FOR A PERIOD OF ONE HUNDRED EIGHTY (180 DAYS) BEGINNING O

January 26, 2021 EX1A-11 CONSENT

- EXHIBIT 11.1

EX1A-11 CONSENT 5 tm211851d5ex11-1.htm EXHIBIT 11.1 Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma, Inc. and Subsidiaries contained in this Offering Statement on Amendment No. 3 to Form 1-A (File No. 024-11228). We consent to the use of the aforementioned r

January 26, 2021 PART II AND III

- PART II AND III

TABLE OF CONTENTS Post-Qualification Offering Circular Amendment No. 3 File No.: 024-11228 Explanatory Note This post-qualification offering circular amendment no. 3 amends the Form 1-A offering statement qualified by the U.S. Securities and Exchange Commission (the “Commission”) on September 23, 2020, as amended by post-qualification offering circular amendment no. 1, which was qualified by the C

January 26, 2021 EX1A-12 OPN CNSL

- EX1A-12 OPN CNSL

Exhibit 12.1 January 26, 2021 Board of Directors Scopus Biopharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 RE: Scopus Biopharma Inc. Opinion Letter Gentlemen: We have acted as counsel to Scopus Biopharma Inc., a Delaware corporation (the “Company”), in connection with the post qualification Offering Statement on Form 1-A (the “Offering Statement”), initially filed on January 1

January 20, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 19, 2021 SCOPUS BIOPHARMA INC.

January 20, 2021 EX-99.2

Scopus BioPharma Announces Completion of Clinical Lot Manufacture Manufactured Lot Fulfills Requirements for Planned Phase 1 Clinical Trial Key milestone to enable finalization of IND package for submission to FDA

Exhibit 99.2 Scopus BioPharma Announces Completion of Clinical Lot Manufacture Manufactured Lot Fulfills Requirements for Planned Phase 1 Clinical Trial Key milestone to enable finalization of IND package for submission to FDA New York, New York, January 19, 2021 – Scopus BioPharma Inc. (Nasdaq: “SCPS”) today announced the completion of clinical lot manufacturing fulfilling the requirements for th

January 20, 2021 EX-99.1

Follow - On Offering Presentation January 202 1

Exhibit 99.1 Follow - On Offering Presentation January 202 1 Disclaimers Scopus BioPharma Inc . (“Scopus”) has filed an offering statement (including an offering circular) with the Securities and Exchange Commission (“SEC”) for the offering of Scopus shares of common stock to which this presentation relates . You should read the offering circular and other documents Scopus has filed with SEC for m

January 15, 2021 PART II AND III

- PART II AND III

PART II AND III 2 tm211851-21apos.htm PART II AND III TABLE OF CONTENTS Post-Qualification Offering Circular Amendment No. 2 File No.: 024-11228 Explanatory Note This post-qualification offering circular amendment no. 2 amends the Form 1-A offering statement qualified by the U.S. Securities and Exchange Commission (the “Commission”) on September 23, 2020, as amended by post-qualification offering

January 15, 2021 EX1A-11 CONSENT

- EXHIBIT 11.1

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Amendment No. 2 to Form 1-A (File No. 024-11228). We consent to the use of the aforementioned report in the Offering Statement on Form 1-A, and to t

December 17, 2020 253G1

- 253G1

TABLE OF CONTENTS  Filed Pursuant to Rule 253(g)(1)  File No. 024-11228 Offering Circular 500,000 Shares Common Stock This is a public offering of our common stock. The public offering price is $5.50 per share. There are no selling stockholders in this offering. Prior to this offering, there has been no public market for our securities. We have applied to have our common stock listed on The Nasdaq

December 10, 2020 CORRESP

Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, NY 10170 December 11, 2020

Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, NY 10170 December 11, 2020 Ms. Laura Crotty Division of Corporation Finance Office of Life Sciences Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Re: Scopus BioPharma Inc. Post Qualification Amendment No. 1 to Form 1-A Filed: December 7, 2020 File No.: 024-11228 Acceleration Request Requested Date: Decembe

December 9, 2020 8-A12B

the description of our common stock in our registration statement on Form 8-A filed with the SEC on December 9, 2021, including any amendments or reports filed for the purpose of updating such description; and

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 SCOPUS BIOPHARMA INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 82-1248020 (State of Incorporation or Organization) (I.R.S. Employer Identification No.) 420 Lexington Avenue,

December 7, 2020 EX1A-3 HLDRS RTS

- EXHIBIT 3.10

Exhibit 3.10 THE REGISTERED HOLDER OF THIS PURCHASE OPTION BY ITS ACCEPTANCE HEREOF, AGREES THAT THIS PURCHASE OPTION SHALL NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, OR HYPOTHECATED, OR BE THE SUBJECT OF ANY HEDGING, SHORT SALE, DERIVATIVE, PUT, OR CALL TRANSACTION THAT WOULD RESULT IN THE EFFECTIVE ECONOMIC DISPOSITION OF THE SECURITIES FOR A PERIOD OF ONE HUNDRED EIGHTY (180 DAYS) IMMEDIATELY

December 7, 2020 PART II AND III

- PART II AND III

TABLE OF CONTENTS Post-Qualification Offering Circular Amendment No. 1 File No.: 024-11228 Explanatory Note This post-qualification offering circular amendment no. 1 amends the Form 1-A offering statement qualified by the U.S. Securities and Exchange Commission on September 23, 2020. TABLE OF CONTENTS An offering statement pursuant to Regulation A relating to these securities has been filed with t

December 7, 2020 EX1A-11 CONSENT

- EXHIBIT 11.1

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Amendment No. 1 to Form 1-A (File No. 024-11228). We consent to the use of the aforementioned report in the Offering Statement on Amendment No. 1 to

December 7, 2020 EX1A-12 OPN CNSL

- EXHIBIT 12.1

Exhibit 12.1 December 7, 2020 Board of Directors Scopus Biopharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 RE: Scopus Biopharma Inc. Opinion Letter Gentlemen: We have acted as counsel to Scopus Biopharma Inc., a Delaware corporation (the “Company”), in connection with the Offering Statement on Form 1-A (the “Offering Statement”), filed by the Company with the Securities and Ex

December 3, 2020 CORRESP

December 3, 2020

Mark J. Wishner Tel: 703-749-1352 [email protected] December 3, 2020 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, DC 20549 Attention: Laura Crotty Celeste Murphy Re: Scopus BioPharma Inc. Post-Effective Amendment to Form 1-A Response dated December 1, 2020 File No. 024-11228 Ladies: On behalf of Scopus BioP

December 1, 2020 CORRESP

December 1, 2020

Mark J. Wishner Tel: 703-749-1352 [email protected] December 1, 2020 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, DC 20549 Attention: Laura Crotty Celeste Murphy Re: Scopus BioPharma Inc. Post-Qualification Amendment to Form 1-A Filed November 17, 2020 File No. 024-11228 Gentlemen: On behalf of Scopus BioPh

November 17, 2020 EX1A-11 CONSENT

- EXHIBIT 11.1

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Form 1-A. We consent to the use of the aforementioned report in the Offering Statement on Form 1-A, and to the use of our name as it appears under t

November 17, 2020 PART II AND III

- PART II AND III

TABLE OF CONTENTS Post-Qualification Offering Circular Amendment No. 1 File No.: 024-11228 Explanatory Note This post-qualification offering circular amendment no. 1 amends the Form 1-A offering statement qualified by the U.S. Securities and Exchange Commission on September 23, 2020. TABLE OF CONTENTS An offering statement pursuant to Regulation A relating to these securities has been filed with t

September 29, 2020 253G1

- 253G1

TABLE OF CONTENTS  Filed Pursuant to Rule 253(g)(1)  File No. 024-11228 Offering Circular 1,000,000 Shares Common Stock This is a public offering of our common stock. The public offering price is expected to be between $5.25 and $5.75 per share. There are no selling stockholders in this offering. Prior to this offering, there has been no public market for our securities. We have applied to have ou

September 29, 2020 253G2

- 253G2

Filed Pursuant to Rule 253(g)(2) File No. 024-11228 SUPPLEMENT NO. 1 DATED SEPTEMBER 29, 2020 TO OFFERING CIRCULAR DATED SEPTEMBER 23, 2020 This supplement to the offering circular of Scopus BioPharma Inc. dated September 23, 2020 (the “Offering Circular”) supplements the Offering Circular, available at https://www.sec.gov/Archives/edgar/data/1772028/000110465920109611/tm2024664-8253g1.htm, by inc

September 29, 2020 253G2

- 253G2

Filed Pursuant to Rule 253(g)(2) File No. 024-11137 EXPLANATORY NOTE This is a supplement to the offering circular of Scopus BioPharma Inc. (the “Company”) dated February 4, 2020 (the “Offering Circular”), available at https://www.sec.gov/Archives/edgar/data/1772028/000110465920013793/tv538014-253g1.htm. Additional information about the Company is available in its annual report on Form 1-K for the

September 25, 2020 1-SA

- FORM 1-SA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-SA x SEMIANNUAL REPORT PURSUANT TO REGULATION A or ¨ SPECIAL FINANCIAL REPORT PURSUANT TO REGULATION A For the fiscal semiannual period ended June 30, 2020 Scopus BioPharma Inc. (Exact name of issuer as specified in its charter) Delaware 82-1248020 (State or other jurisdiction of incorporation or organization) (I.R.S. E

September 21, 2020 CORRESP

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Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 September 21, 2020 Ms. Ada D. Sarmento Division of Corporation Finance Office of Life Sciences Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Re: Scopus BioPharma Inc. Amendment No. 3 to Form 1-A Filed: September 2, 2020 File No.: 024-11228 Qualification Request Requested Date: September 23,

September 2, 2020 EX1A-6 MAT CTRCT

Memorandum of Understanding for Dr. Dmitry Tsvelikhovsky with Yissum Research Development Company Hebrew University of Jerusalem Ltd. dated as of July 28, 2018†

Exhibit 6.2 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. MEMORANDUM OF UNDERSTANDING This Memorandum of Understanding (“MOU”) is made as of July 28, 2018 (the “Effective Date”), by and between Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. of Hi Tech Pa

September 2, 2020 EX1A-6 MAT CTRCT

Memorandum of Understanding for Dr. Alexander Binshtok research with Yissum Research Development Company Hebrew University of Jerusalem Ltd. dated as of July 28, 2018†

Exhibit 6.1 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. MEMORANDUM OF UNDERSTANDING This Memorandum of Understanding (“MOU”) is made as of July 28, 2018 (the “Effective Date”), by and between Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. of Hi Tech Pa

September 2, 2020 EX1A-6 MAT CTRCT

Patent Health Service License Agreement with the National Institutes of Health†

EX1A-6 MAT CTRCT 7 tm2024664d7ex6-5.htm EXHIBIT 6.5 Exhibit 6.5 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. PUBLIC HEALTH SERVICE PATENT LICENSE AGREEMENT – EXCLUSIVE This Agreement is based on the model Patent License Exclusive Agreement adopted by the U.S. Public Health Service (“P

September 2, 2020 EX1A-6 MAT CTRCT

Research and License Agreement with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., dated August 8, 2019†

Exhibit 6.14 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. RESEARCH AND LICENSE AGREEMENT This Research and License Agreement (“Agreement”) is made in Jerusalem this 8 day of August 2019 (the “Effective Date”), by and between: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSIT

September 2, 2020 EX1A-6 MAT CTRCT

Clil Medical Ltd. Management Services Agreement*

Exhibit 6.8 MANAGEMENT SERVICES AGREEMENT This MANAGEMENT SERVICES AGREEMENT ("Agreement") is made and entered into as of the 1st day of September, 2017, by and between Clil Medical Ltd., an Israeli corporation (“Clil"), and Project18 Inc., a Delaware corporation ("Company"). WHEREAS, Morris C. Laster, M.D. (“Laster”) is the sole principal of Clil; and WHEREAS, the Company desires that Clil make L

September 2, 2020 EX1A-6 MAT CTRCT

Research and License Agreement with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., dated March 5, 2019†

Exhibit 6.6 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. RESEARCH AND LICENSE AGREEMENT This Research and License Agreement (“Agreement”) is made in Jerusalem this 5 day of March 2019 (the “Effective Date”), by and between: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY

September 2, 2020 EX1A-11 CONSENT

Consent of Citrin Cooperman & Company, LLP

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Amendment No. 3 to Form 1-A (File No. 024-11228). We consent to the use of the aforementioned report in the Offering Statement on Amendment No. 3 to

September 2, 2020 EX1A-6 MAT CTRCT

HCFP/Strategy Advisors LLC Management Services Agreement*

Exhibit 6.9 MANAGEMENT SERVICES AGREEMENT This MANAGEMENT SERVICES AGREEMENT ("Agreement") is made and entered into as of the 1st day of September, 2017, by and between HCFP/Strategy Advisors LLC, a Delaware limited liability company (“HCFP”), and Project18 Inc., a Delaware corporation ("Company"). WHEREAS, HCFP desires to provide management services to the Company; and WHEREAS, the Company desire

September 2, 2020 PART II AND III

- PART II AND III

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on September 2, 2020 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

September 2, 2020 EX1A-6 MAT CTRCT

Cooperative Research and Development Agreement with the National Institutes of Health†

Exhibit 6.3 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT This Agreement is based on the model Cooperative Research and Development Agreement (“CRADA”) adopted by the U.S. Public Health Service (“PHS”) Technology Tran

September 2, 2020 EX1A-6 MAT CTRCT

Second Amendment to Cooperative Research and Development Agreement†

Exhibit 6.4 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institute On Alcohol Abuse And Alcoholism National Institutes of Health 5625 Fishers Lane Bethesda, MD 20892 USA Second Amendment To the Cooperative Research and Development Agree

September 2, 2020 EX1A-6 MAT CTRCT

Exclusive License Agreement with City of Hope for CO-sTiRNA†

Exhibit 6.17 PORTIONS OF THIS EXHIBIT HAVE BEEN REDACTED AND ARE SUBJECT TO A CONFIDENTIAL INFORMATION REQUEST FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. exclusive LICENSE AGREEMENT THIS EXCLUSIVE LICENSE AGREEMENT (the “Agreement”) is made and entered into as of the 10th day of June 2020 (the “Effective Date”) by and between Scopus BioPharma Inc., a Delaware corporation with a

August 10, 2020 PART II AND III

- PART II AND III

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on August 10, 2020 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 10, 2020 CORRESP

-

Mark J. Wishner Tel: 703-749-1352 [email protected] United States securities and exchange commission logo August 10, 2020 VIA EDGAR CORRESPONDENCE United States Securities and Exchange Commission Division of Corporate Finance Office of Life Sciences 100 F Street, N.E. Washington, DC 20549 Attention: Ada D. Sarmento Celeste Murphy Re: Scopus BioPharma Inc. Amendment No. 1 to Offering Statement on

August 10, 2020 EX1A-1 UNDR AGMT

Form of Underwriting Agreement

Exhibit 1.1 UNDERWRITING AGREEMENT August [ ], 2020 The Benchmark Company, LLC 150 East 58th St., 17th Floor New York, NY 10155 As Representative of the several Underwriters named on Schedule 1 attached hereto Ladies and Gentlemen: The undersigned, Scopus BioPharma Inc., a Delaware corporation (the “Company”), hereby confirms its agreement (this “Agreement”) with The Benchmark Company, LLC (herein

August 10, 2020 EX1A-11 CONSENT

Consent of Citrin Cooperman & Company, LLP

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Amendment No. 2 to Form 1-A (File No. 024-11228). We consent to the use of the aforementioned report in the Offering Statement on Amendment No. 2 to

August 10, 2020 EX1A-6 MAT CTRCT

Kilinwata Investments Pty Ltd Management Services Agreement*

Exhibit 6.19 Scopus BioPharma Inc. 420 Lexington Avenue Suite 300 New York, New York 10170 Life Science Portfolio Managers Attention: Mr Paul Hopper 101/50 McLachlan Avenue RUSHCUTTERS BAY NSW 2011 Dear Paul, Appointment as Co-Chairman This letter agreement (Agreement) outlines the terms on which Kilinwata Investments Pty Ltd, as trustee for the Life Science Portfolio Managers Trust (Kilinwata), h

July 22, 2020 EX1A-6 MAT CTRCT

Conditional Stock Purchase Agreement dated as of June 8, 2020

Exhibit 6.18 CONDITIONAL STOCK PURCHASE AGREEMENT by and among SCOPUS BIOPHARMA INC. and THE SELLERS PARTY HERETO dated as of June 8, 2020 CONDITIONAL STOCK PURCHASE AGREEMENT This CONDITIONAL STOCK PURCHASE AGREEMENT (this “Agreement”), dated as of June 8, 2020, is entered into among (i) Scopus BioPharma Inc., a Delaware corporation (“Purchaser”), (ii) Bioscience Oncology Pty Ltd (ACN: 632 972 39

July 22, 2020 CORRESP

-

Mark J. Wishner Tel: 703-749-1352 [email protected] July 22, 2020 VIA EDGAR CORRESPONDENCE United States Securities and Exchange Commission Division of Corporate Finance Office of Life Sciences 100 F Street, N.E. Washington, DC 20549 Attention: Ada D. Sarmento Celeste Murphy Re: Scopus BioPharma Inc. Offering Statement on Form 1-A Filed May 29, 2020 File No. 024-11228 Ladies: On behalf of Scopus

July 22, 2020 PART II AND III

- PART II AND III

As filed with the Securities and Exchange Commission on July 22, 2020 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

July 22, 2020 EX1A-6 MAT CTRCT

Exclusive License Agreement with City of Hope for STAT3 Inhibitor+

Exhibit 6.17 exclusive LICENSE AGREEMENT THIS EXCLUSIVE LICENSE AGREEMENT (the “Agreement”) is made and entered into as of the 10th day of June 2020 (the “Effective Date”) by and between Scopus BioPharma Inc., a Delaware corporation with a principal place of business at 420 Lexington Avenue, New York, New York 10170 (“Scopus”), and City of Hope, a California nonprofit public benefit corporation lo

July 22, 2020 EX1A-6 MAT CTRCT

Amended and Restated Employment Agreement with Ashish P. Sanghrajka*

Exhibit 6.15 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (this “Agreement”) is dated the 10th day of June, 2020, between Scopus BioPharma Inc., a Delaware corporation (“Company”), and Ashish P. Sanghrajka (“Executive”). RECITALS WHEREAS, Company entered into an Employment Agreement with Executive dated as of August 1, 2019 (the “Prior Agreement”) and Co

July 22, 2020 EX1A-11 CONSENT

Consent of Citrin Cooperman & Company, LLP

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Amendment No. 1 to Form 1-A (File No. 024-11228). We consent to the use of the aforementioned report in the Offering Statement on Amendment No. 1 to

June 12, 2020 253G2

- 253G2

Filed Pursuant to Rule 253(g)(2) File No. 024-11137 EXPLANATORY NOTE This is a supplement to the offering circular of Scopus BioPharma Inc. (the “Company”) dated February 4, 2020 (the “Offering Circular”), available at https://www.sec.gov/Archives/edgar/data/1772028/000110465920013793/tv538014-253g1.htm. Additional information about the Company is available in its annual report filed on Form 1-K f

May 29, 2020 PART II AND III

- PART II AND III

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) Delaware (State of other jurisdiction of incorporation or organization) 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 (Address, including zip code, and tele

May 29, 2020 EX1A-11 CONSENT

Consent of Citrin Cooperman & Company, LLP

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma Inc. and Subsidiaries contained in this Offering Statement on Form 1-A. We consent to the use of the aforementioned report in the Offering Statement on Form 1-A, and to the use of our name as it appears under t

May 18, 2020 253G2

- 253G2

Filed Pursuant to Rule 253(g)(2) File No. 024-11137 SUPPLEMENT DATED MAY 18, 2020 TO OFFERING CIRCULAR DATED FEBRUARY 4, 2020 This supplement to the offering circular supplements the offering circular of Scopus BioPharma Inc. dated February 4, 2020, as the same may be amended or supplemented from time to time, a copy of which may be accessed here, by incorporating by reference our annual report on

May 15, 2020 EX1K-6 MAT CTRCT

Second Amendment to HCFP/Portfolio Services LLC Management Services Agreement^^^

Exhibit 6.12 SCOPUS BIOPHARMA INC. 420 Lexington Avenue, Suite 300 New York, New York 10170 July 10, 2019 Robert J. Gibson, CFA Managing Director HCFP/Portfolio Services LLC 420 Lexington Avenue, Suite 300 New York, New York 10170 Dear Rob: Reference is made to that certain management services agreement between HCFP/Portfolio Services LLC ("Portfolio Services"), assignee of HCFP/Strategy Advisors

May 15, 2020 EX1K-3 HLDRS RTS

Form of Amended Private Placement Securities Purchase Agreement^^^

Exhibit 3.7 SCOPUS BIOPHARMA INC. SECURITIES PURCHASE AGREEMENT IN MAKING AN INVESTMENT DECISION, INVESTORS MUST RELY ON THEIR OWN EXAMINATION OF THE COMPANY, INCLUDING THE MERITS AND RISKS INVOLVED. NEITHER THE NOTE NOR WARRANT HAS BEEN RECOMMENDED BY ANY FEDERAL OR STATE SECURITIES COMMISSION OR REGULATORY AUTHORITY. FURTHERMORE, THE FOREGOING AUTHORITIES HAVE NOT CONFIRMED THE ACCURACY OR DETER

May 15, 2020 EX1K-3 HLDRS RTS

Form of Convertible Promissory Note

Exhibit 3.9 THIS NOTE AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND HAVE BEEN ACQUIRED FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF, AND MAY NOT BE SOLD, ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGI

May 15, 2020 EX1K-6 MAT CTRCT

HCFP/Strategy Advisors LLC/Portfolio Services LLC Assignment Agreement^^^

Exhibit 6.10 HCFP/Strategy Advisors LLC 420 Lexington Avenue, Suite 300 New York, New York 10170 January 9, 2018 Dr. Morris C. Laster Co-Chairman and Chief Executive Officer Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 Dear Morris: Reference is made to that certain management services agreement between HCFP/Strategy Advisors LLC and Scopus BioPharma Inc. (formerly

May 15, 2020 EX1K-3 HLDRS RTS

Form of Company Direct Offering Securities Purchase Agreement^^^

Exhibit 3.6 SCOPUS BIOPHARMA INC. SECURITIES PURCHASE AGREEMENT IN MAKING AN INVESTMENT DECISION, INVESTORS MUST RELY ON THEIR OWN EXAMINATION OF THE COMPANY, INCLUDING THE MERITS AND RISKS INVOLVED. NEITHER THE NOTE NOR WARRANT HAS BEEN RECOMMENDED BY ANY FEDERAL OR STATE SECURITIES COMMISSION OR REGULATORY AUTHORITY. FURTHERMORE, THE FOREGOING AUTHORITIES HAVE NOT CONFIRMED THE ACCURACY OR DETER

May 15, 2020 PART II

- PART II

PART II INFORMATION TO BE INCLUDED IN REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 15, 2020 EX1K-6 MAT CTRCT

Amendment to HCFP/Portfolio Services LLC Management Services Agreement^^^

Exhibit 6.11 SCOPUS BIOPHARMA INC. 420 Lexington Avenue, Suite 300 New York, NY 10170 February 25, 2019 Robert J. Gibson, CFA Managing Director HCFP/Portfolio Services LLC 420 Lexington Avenue, Suite 300 New York, NY 10170 Dear Rob: Reference is made to that certain management services agreement between HCFP/Portfolio Services LLC ("HCFP") assignee of HCFP/Strategy Advisors LLC, and Scopus BioPhar

May 15, 2020 EX1K-11 CONSENT

Consent of Citrin Cooperman & Company, LLP

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2020, with respect to the consolidated financial statements of Scopus BioPharma, Inc. and Subsidiaries contained in this Form 1-K. We consent to the use of the aforementioned report in the Offering Statement on Form 1-A (File No. 024-11137) qualified with the Securities and Exchange Commis

May 15, 2020 EX1K-3 HLDRS RTS

Form of X Warrant^^^

Exhibit 3.8 THESE WARRANTS AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), HAVE BEEN OR WILL BE ACQUIRED FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF, AND MAY NOT BE SOLD, ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED WITHOUT AN EF

February 10, 2020 253G1

200,000 Series A Units

TABLE OF CONTENTS Filed Pursuant to Rule 253(g)(1) File No. 024-11137? Offering Circular 200,000 Series A Units This is an initial public offering of our securities. We are offering 200,000 of our Series A Units, or A Units. The offering price is $5.00 per A Unit. Each A Unit consists of one share of our common stock and two Series W Warrants, or W Warrants. Each W Warrant is exercisable for one S

January 31, 2020 CORRESP

Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 January 31, 2020

Scopus BioPharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 January 31, 2020 Irene Paik Division of Corporate Finance Office of Life Sciences Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Re: Scopus BioPharma Inc. Amendment No. 1 to Offering Statement on Form 1-A Filed: January 16, 2020 File No.: 024-11137 Acceleration Request Requeste

January 16, 2020 EX1A-4 SUBS AGMT

Form of Subscription Agreement^

Exhibit 4.1 SUBSCRIPTION AGREEMENT Name of Investor: To: Scopus BioPharma Inc. Offering of Series A Units, each such unit consisting of one share of common stock and two Series W Warrants 1. Subscription. The undersigned hereby tenders this subscription and applies to purchase the number of Series A Units (“Units”) in Scopus BioPharma Inc., a Delaware corporation (the "Company") indicated below, p

January 16, 2020 EX1A-6 MAT CTRCT

Transfer Agency and Registrar Services Agreement with Continental Stock Transfer & Trust Company dated as of July 24, 2019^^

Exhibit 6.13 transfer agency and registrar services agreement This Transfer Agency and Registrar Services Agreement (this ?Agreement?), dated as of July 24, 2019 is between Scopus BioPharma Inc., a Delaware corporation (the ?Company?) and Continental Stock Transfer & Trust Company, a New York limited purpose trust company (?CST?). 1. Appointment as Transfer Agent. The Company hereby appoints CST t

January 16, 2020 EX1A-12 OPN CNSL

January 16, 2020

Exhibit 12.1 January 16, 2020 Board of Directors Scopus Biopharma Inc. 420 Lexington Avenue, Suite 300 New York, New York 10170 RE: Scopus Biopharma Inc. Opinion Letter Gentlemen: We have acted as counsel to Scopus Biopharma Inc., a Delaware corporation (the ?Company?), in connection with the Offering Statement on Form 1-A (the ?Offering Statement?), filed by the Company with the Securities and Ex

January 16, 2020 EX1A-3 HLDRS RTS

Form of Warrant Agreement^^

Exhibit 3.3 WARRANT AGREEMENT between SCOPUS BIOPHARMA INC. and CONTINENTAL STOCK TRANSFER & TRUST COMPANY This Series W and Series Z Warrant Agreement (?Agreement?) made as of , 2020, by and between Scopus BioPharma Inc., a Delaware corporation, with offices at 420 Lexington Avenue, Suite 300, New York, New York 10170 (?Company?), and Continental Stock Transfer & Trust Company, a New York corpora

January 16, 2020 EX1A-3 HLDRS RTS

Form of A Unit Certificate^^

Exhibit 3.4 SCOPUS BIOPHARMA INC. The Company will furnish without charge to each unitholder who so requests, a statement of the powers, designations, preferences and relative, participating, optional or other special rights of each class of stock or series thereof of the Company and the qualifications, limitations, or restrictions of such preferences and/or rights. The following abbreviations, wh

January 16, 2020 PART II AND III

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) (State of other jurisdiction of

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) Delaware (State of other jurisdiction of incorporation or organization) 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 (Address, including zip code, and tele

January 16, 2020 EX1A-11 CONSENT

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated April 3, 2019, with respect to the consolidated financial statements of Scopus BioPharma, Inc. and Subsidiaries contained in this Registration Statement and Prospectus. We consent to the use of the aforementioned report in the Offering Statement on Form 1-A and Prospectus, and to the use of our na

January 16, 2020 EX1A-3 HLDRS RTS

Form of W Warrant Certificate^^

Exhibit 3.2 Number WW INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE SERIES W WARRANTS CUSIP 809171 11 9 THIS SERIES A WARRANT SHALL BE VOID IF NOT EXERCISED PRIOR TO THE EXPIRATION OF THE EXERCISE PERIOD PROVIDED FOR IN THE WARRANT AGREEMENT DESCRIBED BELOW This certifies that, or registered assigns, is the registered holder of Series W Warrants (?Series W Warrants? and each a ?Series W War

January 7, 2020 EX1A-11 CONSENT

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 11.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated April 3, 2019, with respect to the consolidated financial statements of Scopus BioPharma, Inc. and Subsidiaries contained in this Registration Statement and Prospectus. We consent to the use of the aforementioned report in the Offering Statement on Form 1-A and Prospectus, and to the use of our na

January 7, 2020 PART II AND III

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) (State of other jurisdiction of

PART II AND III 2 tm201367d1partiiandiii.htm PART II AND III UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) Delaware (State of other jurisdiction of incorporation or organization) 420 Lexington Avenue, Suite 300 New York, New Yor

December 19, 2019 PART II AND III

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) (State of other jurisdiction of

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) Delaware (State of other jurisdiction of incorporation or organization) 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 (Address, including zip code, and tele

December 19, 2019 DOSLTR

175,000 (options) 450,000 (warrant) 100,000 (options) 300,000 (option) 25,000 (option)

Mark J. Wishner Tel: 703-749-1352 [email protected] December 19, 2019 VIA EDGAR CORRESPONDENCE United States Securities and Exchange Commission Division of Life Sciences Office of Technology 100 F Street, N.E. Washington, DC 20549 Attention: Christine Torney Lisa Vanjoske Irene Paik Mary Beth Breslin Re: Scopus BioPharma Inc. Draft Offering Statement on Form 1-A Submitted November 15, 2019 CIK No

December 5, 2019 RW

December 5, 2019

December 5, 2019 VIA EDGAR CORRESPONDENCE Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

November 15, 2019 PART II AND III

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) (State of other jurisdiction of

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 1-A REGULATION A OFFERING CIRCULAR UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of issuer as specified in its charter) Delaware (State of other jurisdiction of incorporation or organization) 420 Lexington Avenue, Suite 300 New York, New York 10170 (212) 479-2513 (Address, including zip code, and tele

November 1, 2019 S-1/A

As filed with the Securities and Exchange Commission on November 1, 2019

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on November 1, 2019 Registration No.

November 1, 2019 EX-10.13

Form of Common Stock Purchase Warrant

Exhibit 10.13 NEITHER THIS WARRANT NOR THE SHARES OF COMMON STOCK FOR WHICH THIS WARRANT IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?SECURITIES ACT?), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFEC

November 1, 2019 EX-10.12

Employment Agreement with Ashish P. Sanghrajka^

Exhibit 10.12 EMPLOYMENT AGREEMENT This Employment Agreement (this ?Agreement?) is effective as of August 1, 2019, between Scopus BioPharma Inc., a Delaware corporation (?Company?) and Ashish P. Sanghrajka (?Executive?). RECITALS WHEREAS, Company desires to provide for the employment of Executive by Company, and Executive desires to accept such employment, in each case subject to the terms and upo

October 2, 2019 FWP

Building the Future of Cannabinoid Therapeutics Corporate Presentation October 2019 Issuer Free Writing Prospectus Dated October 2, 2019 Filed pursuant to Rule 433 under the Securities Act of 1933, as amended, in connection with Registration Statemen

Building the Future of Cannabinoid Therapeutics Corporate Presentation October 2019 Issuer Free Writing Prospectus Dated October 2, 2019 Filed pursuant to Rule 433 under the Securities Act of 1933, as amended, in connection with Registration Statement No.

September 27, 2019 FWP

Building the Future of Cannabinoid Therapeutics Corporate Presentation September 27, 2019 Issuer Free Writing Prospectus Dated September 27, 2019 Filed pursuant to Rule 433 under the Securities Act of 1933, as amended, in connection with Registration

Building the Future of Cannabinoid Therapeutics Corporate Presentation September 27, 2019 Issuer Free Writing Prospectus Dated September 27, 2019 Filed pursuant to Rule 433 under the Securities Act of 1933, as amended, in connection with Registration Statement No.

August 15, 2019 EX-10.10

2018 Equity Incentive Plan^

Exhibit 10.10 scopus biopharma INC. 2018 EQUITY INCENTIVE PLAN 1. Purpose. The purpose of this 2018 EQUITY INCENTIVE PLAN (the ?Plan?) is to assist Scopus BioPharma Inc., a Delaware corporation (the ?Company?), in attracting, motivating, retaining and rewarding high-quality executives and other employees, officers, directors, consultants and other persons who provide services to the Company by ena

August 15, 2019 EX-10.11

Research and License Agreement with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.^+

Exhibit 10.11 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* RESEARCH AND LICENSE AGREEMENT This Research and License Agreement (?Agreement?) is made in Jerusalem this 8 day of August 2019 (the ?Effective Date?), by and between: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE

August 15, 2019 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 UNDERWRITING AGREEMENT September , 2019 The Benchmark Company, LLC 150 East 58th St., 17th Floor New York, NY 10155 As Representative of the several Underwriters named on Schedule 1 attached hereto Ladies and Gentlemen: The undersigned, Scopus BioPharma Inc., a Delaware corporation (the ?Company?), hereby confirms its agreement (this ?Agreement?) with The Benchmark Company, LLC (herein

August 15, 2019 EX-21.1

List of Subsidiaries^

Exhibit 21.1 Subsidiaries of Registrant Vital Spark, Inc. Scopus BioPharma Israel Ltd.

August 15, 2019 EX-4.6

Form of Warrant Issued to Yissum Research Development Corporation of the Hebrew University of Jerusalem, Ltd.^

Exhibit 4.6 NEITHER this Warrant NOR THE SECURITIES INTO WHICH this Warrant is EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED OR APPLICABLE STATE SECURITIES LAWS. Neither this Warrant nor such securities MAY BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1

August 15, 2019 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant^

Exhibit 3.1 Delaware Page 1 The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE RESTATED CERTIFICATE OF ?PROJECT18 INC.?, CHANGING ITS NAME FROM ?PROJECT18 INC.? TO ?SCOPUS BIOPHARMA INC.?, FILED IN THIS OFFICE ON THE ELEVENTH DAY OF DECEMBER, A.D. 2017, AT 5:50 O? CLOCK P.M. /s/ Jeffrey W. Bullock Jef

August 15, 2019 S-1/A

As filed with the Securities and Exchange Commission on August 15, 2019

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on August 15, 2019 Registration No.

August 15, 2019 EX-4.5

Form of Series A Unit Certificate

? Exhibit 4.5 ? 0000001SPECIMENSEE REVERSE FOR IMPORTANT NOTICE REGARDING OWNERSHIP ANDTRANSFER RESTRICTIONS AND CERTAIN OTHER INFORMATIONEach series A unit (?Series A Unit?) consists of one (1) share of common stock, par value $0.001 per share (?Common Stock?), of Scopus BioPharma Inc., a Delaware corporation (the ?Company?), and two (2) series A warrants(the ?Series A Warrants?). Each Series A W

August 15, 2019 EX-4.2

Form of Warrant Certificate

? Exhibit 4.2 ? COUNTERSIGNED AND REGISTERED:CONTINENTAL STOCK TRANSFER & TRUST COMPANYNEW YORK, N.Y.BYWARRANT AGENTAUTHORIZED SIGNATUREINCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARESERIES A WARRANTSSECRETARY CHIEF EXECUTIVE OFFICERThis certifies that , or registered assigns, is the registered holder of Series A Warrants (?Series A Warrants? and each a?Series A Warrant? to purchase Series B

August 15, 2019 EX-3.2

Amended and Restated By-laws of Registrant^

Exhibit 3.2 SCOPUS BIOPHARMA INC. AMENDED AND RESTATED BY-LAWS ARTICLE I Offices Section 1.01 Registered Office. The registered office of Scopus BioPharma Inc. (the "Corporation") will be fixed in the Certificate of Incorporation of the Corporation (the "Certificate of Incorporation"). Section 1.02 Other Offices. The Corporation may have other offices, both within and without the State of Delaware

August 15, 2019 EX-10.7

Form of Scientific Advisory Board Member Agreement^

Exhibit 10.7 SCIENTIFIC ADVISORY BOARD MEMBER AGREEMENT This Scientific Advisory Board Member Agreement (the ?Agreement?) is made as of this day of , 201 (the ?Effective Date?) by and between Scopus BioPharma Inc. (the ?Company?), having a principal place of business at 420 Lexington Avenue, Suite 300, New York, New York 10170, and (the ?Member?) an individual residing at . 1. Engagement. Upon the

August 15, 2019 EX-4.4

Form of Unit Purchase Option

Exhibit 4.4 THE REGISTERED HOLDER OF THIS PURCHASE OPTION BY ITS ACCEPTANCE HEREOF, AGREES THAT THIS PURCHASE OPTION SHALL NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, OR HYPOTHECATED, OR BE THE SUBJECT OF ANY HEDGING, SHORT SALE, DERIVATIVE, PUT, OR CALL TRANSACTION THAT WOULD RESULT IN THE EFFECTIVE ECONOMIC DISPOSITION OF THE SECURITIES FOR A PERIOD OF ONE HUNDRED EIGHTY (180) DAYS IMMEDIATELY

August 15, 2019 EX-4.1

Form of Common Stock Certificate^

? Exhibit 4.1 ? SEE REVERSE FOR IMPORTANT NOTICE REGARDING OWNERSHIP ANDTRANSFER RESTRICTIONS AND CERTAIN OTHER INFORMATIONFULLY PAID AND NON-ASSESSABLE SHARES OF THE PAR VALUE OF $0.001 EACH OF THE COMMON STOCK OFScopus Biopharma Inc.transferable on the books of the Company in Person or by duly a uthorized attorney, upon surrender of this Certificate properly endorsed. This Certificate and the sh

August 15, 2019 EX-10.9

HCFP/Strategy Advisors LLC Management Services Agreement^

Exhibit 10.9 MANAGEMENT SERVICES AGREEMENT This MANAGEMENT SERVICES AGREEMENT ("Agreement") is made and entered into as of the 1st day of September, 2017, by and between HCFP/Strategy Advisors LLC, a Delaware limited liability company (?HCFP?), and Project18 Inc., a Delaware corporation ("Company"). WHEREAS, HCFP desires to provide management services to the Company; and WHEREAS, the Company desir

August 15, 2019 EX-10.8

Clil Medical Ltd. Management Services Agreement^

Exhibit 10.8 MANAGEMENT SERVICES AGREEMENT This MANAGEMENT SERVICES AGREEMENT ("Agreement") is made and entered into as of the 1st day of September, 2017, by and between Clil Medical Ltd., an Israeli corporation (?Clil"), and Project18 Inc., a Delaware corporation ("Company"). WHEREAS, Morris C. Laster, M.D. (?Laster?) is the sole principal of Clil; and WHEREAS, the Company desires that Clil make

August 15, 2019 EX-4.3

Form of Warrant Agreement with Continental Stock Transfer and Trust Company

Exhibit 4.3 WARRANT AGREEMENT between SCOPUS BIOPHARMA INC. and CONTINENTAL STOCK TRANSFER & TRUST COMPANY This Series A and Series B Warrant Agreement (?Agreement?) made as of September , 2019, by and between Scopus BioPharma Inc., a Delaware corporation, with offices at 420 Lexington Avenue, Suite 300, New York, New York 10170 (?Company?), and Continental Stock Transfer & Trust Company, a New Yo

July 1, 2019 S-1/A

Power of Attorney^

As filed with the Securities and Exchange Commission on July 1, 2019 Registration No.

June 19, 2019 EX-10.5

Patent Health Service License Agreement with the National Institute of Health^+

Exhibit 10.5 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* PUBLIC HEALTH SERVICE PATENT LICENSE AGREEMENT ? EXCLUSIVE This Agreement is based on the model Patent License Exclusive Agreement adopted by the U.S. Public Health Service (?PHS?) Technology Transfer Policy Boa

June 19, 2019 EX-10.3

Cooperative Research and Development Agreement with the National Institute of Health^+

Exhibit 10.3 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT This Agreement is based on the model Cooperative Research and Development Agreement (?CRADA?) adopted by the U.S. Public Health Service (?PHS?

June 19, 2019 S-1/A

As filed with the Securities and Exchange Commission on June 19, 2019

As filed with the Securities and Exchange Commission on June 19, 2019 Registration No.

June 19, 2019 EX-10.2

Memorandum of Understanding for Dr. Dmitry Tsvelikhovsky with Yissum Research Development Company Hebrew University of Jerusalem Ltd. dated as of July 28, 2018^+

Exhibit 10.2 REDACTED *Certain identified information has been excluded from the exhibit because it is both: (i) not material and (ii) would be competitively harmful if publicly disclosed.* MEMORANDUM OF UNDERSTANDING This Memorandum of Understanding (?MOU?) is made as of July 28, 2018 (the ?Effective Date?), by and between Yissum Research Development Company of the Hebrew University of Jerusalem

June 19, 2019 EX-10.1

Memorandum of Understanding for Dr. Alexander Binshtok research with Yissum Research Development Company Hebrew University of Jerusalem Ltd. dated as of July 28, 2018^+

Exhibit 10.1 REDACTED *Certain identified information has been excluded from the exhibit because it is both: (i) not material and (ii) would be competitively harmful if publicly disclosed.* MEMORANDUM OF UNDERSTANDING This Memorandum of Understanding (?MOU?) is made as of July 28, 2018 (the ?Effective Date?), by and between Yissum Research Development Company of the Hebrew University of Jerusalem

June 19, 2019 EX-10.6

Research and License Agreement with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.^+

Exhibit 10.6 REDACTED *Certain identified information has been excluded from the exhibit because it is both: (i) not material and (ii) would be competitively harmful if publicly disclosed.* RESEARCH AND LICENSE AGREEMENT This Research and License Agreement (?Agreement?) is made in Jerusalem this 5 day of March 2019 (the ?Effective Date?), by and between: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE

June 19, 2019 EX-10.4

Second Amendment to Cooperative Research and Development Agreement^+

Exhibit 10.4 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institute On Alcohol Abuse And Alcoholism National Institutes of Health 5625 Fishers Lane Bethesda, MD 20892 USA Second Amendment To the Cooperative Research and

June 18, 2019 EX-10.5

Patent Health Service License Agreement with the National Institute of Health

Exhibit 10.5 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* PUBLIC HEALTH SERVICE PATENT LICENSE AGREEMENT ? EXCLUSIVE This Agreement is based on the model Patent License Exclusive Agreement adopted by the U.S. Public Health Service (?PHS?) Technology Transfer Policy Boa

June 18, 2019 EX-10.3

Cooperative Research and Development Agreement with the National Institute of Health

Exhibit 10.3 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT This Agreement is based on the model Cooperative Research and Development Agreement (?CRADA?) adopted by the U.S. Public Health Service (?PHS?

June 18, 2019 EX-10.4

Second Amendment to Cooperative Research and Development Agreement

Exhibit 10.4 REDACTED *Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.* DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institute On Alcohol Abuse And Alcoholism National Institutes of Health 5625 Fishers Lane Bethesda, MD 20892 USA Second Amendment To the Cooperative Research and

June 18, 2019 S-1

As filed with the Securities and Exchange Commission on _______, 2019

As filed with the Securities and Exchange Commission on , 2019 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of registrant as specified in its constitutional documents) Delaware 2834 82-1248020 (State or other jurisdiction of incorporation or organizati

June 18, 2019 EX-10.1

Memorandum of Understanding for Dr. Alexander Binshtok research with Yissum Research Development Company Hebrew University of Jerusalem Ltd. dated as of July 28, 2018†

Exhibit 10.1 REDACTED *Certain identified information has been excluded from the exhibit because it is both: (i) not material and (ii) would be competitively harmful if publicly disclosed.* MEMORANDUM OF UNDERSTANDING This Memorandum of Understanding (?MOU?) is made as of July 28, 2018 (the ?Effective Date?), by and between Yissum Research Development Company of the Hebrew University of Jerusalem

June 18, 2019 EX-10.2

Memorandum of Understanding for Dr. Dmitry Tsvelikhovsky with Yissum Research Development Company Hebrew University of Jerusalem Ltd. dated as of July 28, 2018

Exhibit 10.2 REDACTED *Certain identified information has been excluded from the exhibit because it is both: (i) not material and (ii) would be competitively harmful if publicly disclosed.* MEMORANDUM OF UNDERSTANDING This Memorandum of Understanding (?MOU?) is made as of July 28, 2018 (the ?Effective Date?), by and between Yissum Research Development Company of the Hebrew University of Jerusalem

June 18, 2019 EX-10.6

Research and License Agreement with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Exhibit 10.6 REDACTED *Certain identified information has been excluded from the exhibit because it is both: (i) not material and (ii) would be competitively harmful if publicly disclosed.* RESEARCH AND LICENSE AGREEMENT This Research and License Agreement (?Agreement?) is made in Jerusalem this 5 day of March 2019 (the ?Effective Date?), by and between: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE

May 17, 2019 DRS/A

As filed with the Securities and Exchange Commission on _______, 2019

As filed with the Securities and Exchange Commission on , 2019 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SCOPUS BIOPHARMA INC. (Exact name of registrant as specified in its constitutional documents) Delaware 2834 82-1248020 (State or other jurisdiction of incorporation or organizati

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